Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

laurin-Sandrow syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

laurin-Sandrow syndrome

MONDO:0007615

Also known as:Sandrow syndromemirror hands and feets-nasal defects syndromeLSS

Overview

Laurin-Sandrow syndrome (LSS) is characterized by complete polysyndactyly of the hands, mirror feet and nose anomalies (hypoplasia of the nasal alae and short columella), often associated with ulnar and/or fibular duplication (and sometimes tibial agenesis). It has been described in less than 20 cases. Some cases with the same clinical signs but without nasal defects have also been reported, and may represent the same entity. The etiology of LSS is unknown. Different modes of inheritance have been suggested.

GeneticsAutosomal dominant · LMBR1 (chr 7)

ResearchLimited published research (3 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Triphalangeal thumb, Short foot, Underdeveloped nasal alae, and Abnormality of the face and 7 more.

Organ System	Phenotype Count	Example Features
Arms and legs	3	Short foot, Hand polydactyly, Broad foot
Head and neck

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

LMBR1 encodes limb development membrane protein 1 (490 aa). Putative membrane receptor Highest expression in Adrenal Gland (16.9 TPM) and Testis (14.8 TPM).

Laurin-Sandrow syndrome is associated with mutations in the LMBR1 gene on chromosome 7.

LMBR1 is classified as a druggable target with score 0.0.

Diagnosis

Genetic testing for LMBR1 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for laurin-Sandrow syndrome.

5 publications have been identified in PubMed for laurin-Sandrow syndrome. Kisho has analyzed 3 by research type. Research spans Basic Science / Preclinical (100%).

Recent Publications

Chand K (2026). [PMID: 42068746](https://pubmed.ncbi.nlm.nih.gov/42068746/). *Biochem Biophys Res Commun*. [Basic Science / Preclinical]
Straulino E (2025). [PMID: 40081756](https://pubmed.ncbi.nlm.nih.gov/40081756/). *Neuropsychologia*. [Basic Science / Preclinical]
Lu X (2024). [PMID: 39293386](https://pubmed.ncbi.nlm.nih.gov/39293386/). *Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology*. [Basic Science / Preclinical]

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 2:53 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:135750

Orphanet

European rare disease database

Orphanet:2378

GARD

Genetic and Rare Diseases Info Center

GARD:155

Questions for Your Care Team

→Should I pursue genetic testing for LMBR1, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

laurin-Sandrow syndrome

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features