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postpoliomyelitis syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

postpoliomyelitis syndrome

MONDO:0017416

Also known as:Post Polio Syndromepostpolio sequelaepostpolio syndrome

Find Clinical TrialsTrials

Overview

Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis, 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.

Clinical Trials5 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for postpoliomyelitis syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

5 clinical trials registered, 2 recruiting. Interventions under study include medical devices and procedural interventions. Pipeline includes 3 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06320444](https://clinicaltrials.gov/study/NCT06320444)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 10:42 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2942

GARD

Genetic and Rare Diseases Info Center

GARD:4454

Questions for Your Care Team

→Are any of the 5 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	11	26%
Disease patterns and progression	10	23%
Patient case studies	8	19%
Clinical study results	5	12%
Other research	3	7%
Testing and diagnosis research	3	7%
Laboratory research	3	7%

postpoliomyelitis syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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