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preeclampsia/eclampsia 5 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

preeclampsia/eclampsia 5

MONDO:0013817

Also known as:CORIN preeclampsiaPreeclampsia/eclampsia type 5preeclampsia caused by mutation in CORIN

Overview

Any preeclampsia in which the cause of the disease is a mutation in the CORIN gene.

GeneticsAutosomal dominant · CORIN (chr 4)

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

CORIN encodes corin, serine peptidase (1,042 aa). Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Highest expression in Heart Atrial Appendage (27.7 TPM) and Heart Left Ventricle (10.0 TPM).

Preeclampsia/eclampsia 5 is associated with mutations in the CORIN gene on chromosome 4.

The CORIN protein participates in CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) pathway.

CORIN is classified as a druggable target (Cell Surface, Druggable Genome, Enzyme, and Protease categories) with score 0.0.

Diagnosis

Genetic testing for CORIN is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for preeclampsia/eclampsia 5 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for preeclampsia/eclampsia 5.

92 publications have been identified in PubMed for preeclampsia/eclampsia 5. Research spans Epidemiology / Natural History (47%), Clinical Trial Publication (24%), and Review / Meta-Analysis (11%).

Research Type	Count	% of Total
Disease patterns and progression	43	47%

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:48 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:614595

GARD

Genetic and Rare Diseases Info Center

GARD:18393

Questions for Your Care Team

→Should I pursue genetic testing for CORIN, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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preeclampsia/eclampsia 5

Overview

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

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