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severe pre-eclampsia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

severe pre-eclampsia

MONDO:0001641

Also known as:Preeclampsia with severe featuresantepartum severe pre-eclampsiapostpartum severe pre-eclampsia

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Overview

Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.

TreatmentsNo approved treatments · 4 in pipeline

Clinical Trials11 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for severe pre-eclampsia has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for severe pre-eclampsia. An additional 4 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for severe pre-eclampsia, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for severe pre-eclampsia. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

11 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 2 PHASE4, 1 PHASE3, 2 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07261956](https://clinicaltrials.gov/study/NCT07261956)

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 11 active clinical trials a good fit for my situation?
→With 4 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Disease patterns and progression	77	36%
Clinical study results	45	21%
Patient case studies	41	19%
Testing and diagnosis research	18	9%
Research summaries	14	7%
Laboratory research	14	7%
Other research	2	1%

severe pre-eclampsia

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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