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primary progressive freezing gait (PPFG) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

primary progressive freezing gait

MONDO:0019160

Also known as:PPFG

Overview

Primary progressive freezing gait is a rare, heterogeneous, progressively incapacitating neurodegenerative disease characterized by freezing of gait (usually during the first 3 years), later associating postural instability, eventually resulting in a wheelchair-bound state. Other features may include mild bradykinesia, rigidity, postural tremor, hyperreflexia, speech disorder and dementia. The disease is unresponsive to dopaminergic treatments.

ResearchLimited published research (6 articles)

Diagnosis

Biomarker and diagnostic research for primary progressive freezing gait has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for primary progressive freezing gait.

6 publications have been identified in PubMed for primary progressive freezing gait. Research spans Case Report / Case Series (50%), Diagnostic / Biomarker (17%), and Clinical Trial Publication (17%).

Recent Publications

Mori Y (2026). [PMID: 41833368](https://pubmed.ncbi.nlm.nih.gov/41833368/). *Rinsho Shinkeigaku*. [Case Report / Case Series]
Ha SH (2026). [PMID: 41634613](https://pubmed.ncbi.nlm.nih.gov/41634613/). *BMC Neurol*. [Case Report / Case Series]
Zemmar A (2025). [PMID: 39557021](https://pubmed.ncbi.nlm.nih.gov/39557021/). *Stereotact Funct Neurosurg*. [Basic Science / Preclinical]
Lim M (2025). [PMID: 40198116](https://pubmed.ncbi.nlm.nih.gov/40198116/). *JMIR Aging*. [Diagnostic / Biomarker]
Sengoku R (2025). [PMID: 40261028](https://pubmed.ncbi.nlm.nih.gov/40261028/). *Mov Disord Clin Pract*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:45 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:75567

GARD

Genetic and Rare Diseases Info Center

GARD:18930

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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primary progressive freezing gait

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team