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pulmonary hypoplasia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pulmonary hypoplasia

MONDO:0800133

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Overview

A respiratory malformation characterized by the presence of both bronchi (albeit rudimentary) and alveoli in an under-developed lobe. Both the size and the weight of the lung are reduced. The true prevalence is not well known (1.4% of all births according to Knox et al. 13), but in cases of premature rupture of membranes at 15-28 weeks gestation, the reported prevalence of pulmonary hypoplasia ranges from 9 to 28%. Factors that contribute to pulmonary hypoplasia include adequate volume of the thoracic cavity, pulmonary fluid dynamics, and abnormal fetal breathing movements.

Clinical Trials5 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for pulmonary hypoplasia has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

5 clinical trials registered, 1 recruiting. Interventions under study include medical devices. Pipeline includes 1 PHASE3, 4 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT03138863](https://clinicaltrials.gov/study/NCT03138863)

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 5 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	35	42%
Patient case studies	16	19%
Disease patterns and progression	11	13%
Laboratory research	8	10%
Testing and diagnosis research	6	7%
New treatment approaches	5	6%
Clinical study results	3	4%

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pulmonary hypoplasia

Overview

Diagnosis

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

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Pulmonary Hypoplasia.

pulmonary hypoplasia

Overview

Diagnosis

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Pulmonary Hypoplasia.