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scleromyxedema without monoclonal gammopathy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

scleromyxedema without monoclonal gammopathy

MONDO:0019585

Overview

Scleromyxedema without monoclonal gammopathy is a form of atypical lichen myxedematosus, characterized by a generalized sclerodermoid infiltration of skin studded with multiple, firm papules of 1-3 mm in diameter involving face (leonine appearance), trunk, and limbs, without monoclonal gammopathy. The involvement of the face can be missing and pruritus may be prominent.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for scleromyxedema without monoclonal gammopathy.

26 publications have been identified in PubMed for scleromyxedema without monoclonal gammopathy. Research spans Case Report / Case Series (65%), Review / Meta-Analysis (23%), and Gene Therapy / Novel Therapeutics (8%).

Research Type	Count	% of Total
Patient case studies	17	65%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:90400

GARD

Genetic and Rare Diseases Info Center

GARD:19144

Questions for Your Care Team

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scleromyxedema without monoclonal gammopathy

Overview

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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