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The secondary stage of syphilis typically that is characterized by generalized rash (including palms and soles), mucocutaneous lesions, and lymphadenopathy. It usually begins one to two months after the primary stage.
Biomarker and diagnostic research for secondary syphilis has been reported in the published literature.
1 clinical trial registered. Interventions under study include drug therapy. Pipeline includes 1 PHASE3. Research is primarily sponsored by academic and government institutions.
295 publications have been identified in PubMed for secondary syphilis. Research spans Case Report / Case Series (57%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (10%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 137 | 57% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 9:38 PM UTC
Research summaries |
48 |
20% |
Disease patterns and progression | 24 | 10% |
Other research | 13 | 5% |
Testing and diagnosis research | 9 | 4% |
Laboratory research | 8 | 3% |
Clinical study results | 3 | 1% |
Chao Maseda B (2026). [PMID: 41671887](https://pubmed.ncbi.nlm.nih.gov/41671887/). *Semergen*. [Case Report / Case Series]
Patel T (2026). [PMID: 41223427](https://pubmed.ncbi.nlm.nih.gov/41223427/). *Am J Dermatopathol*. [Case Report / Case Series]
Armstrong JL (2026). [PMID: 41939646](https://pubmed.ncbi.nlm.nih.gov/41939646/). *Cureus*. [Case Report / Case Series]
Longi AA (2026). [PMID: 41777950](https://pubmed.ncbi.nlm.nih.gov/41777950/). *Cureus*. [Case Report / Case Series]
Aboo MA (2026). [PMID: 42111232](https://pubmed.ncbi.nlm.nih.gov/42111232/). *S Afr J Infect Dis*. [Case Report / Case Series]
Srinivasan S (2026). [PMID: 42080944](https://pubmed.ncbi.nlm.nih.gov/42080944/). *J Epidemiol Glob Health*. [Other]
Cohen PR (2026). [PMID: 41694988](https://pubmed.ncbi.nlm.nih.gov/41694988/). *Cureus*. [Case Report / Case Series]
Tartaglia J (2026). [PMID: 42222700](https://pubmed.ncbi.nlm.nih.gov/42222700/). *Skin Health Dis*. [Other]
Achdiat PA (2026). [PMID: 41868038](https://pubmed.ncbi.nlm.nih.gov/41868038/). *Int J Womens Health*. [Case Report / Case Series]
Toro D (2026). [PMID: 42091060](https://pubmed.ncbi.nlm.nih.gov/42091060/). *Am J Perinatol*. [Case Report / Case Series]