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A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Biomarker and diagnostic research for congenital syphilis has been reported in the published literature.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
2 clinical trials registered, 1 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.
244 publications have been identified in PubMed for congenital syphilis. Research spans Epidemiology / Natural History (45%), Review / Meta-Analysis (14%), and Diagnostic / Biomarker (14%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 110 |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries | 35 | 14% |
Testing and diagnosis research | 33 | 14% |
Patient case studies | 31 | 13% |
Clinical study results | 15 | 6% |
Other research | 14 | 6% |
Laboratory research | 6 | 2% |
McColl ER (2026). [PMID: 42146369](https://pubmed.ncbi.nlm.nih.gov/42146369/). *bioRxiv*. [Basic Science / Preclinical]
Ryan C (2026). [PMID: 41283732](https://pubmed.ncbi.nlm.nih.gov/41283732/). *Infect Dis (Lond)*. [Review / Meta-Analysis]
Simone J (2026). [PMID: 42236154](https://pubmed.ncbi.nlm.nih.gov/42236154/). *Sex Transm Infect*. [Review / Meta-Analysis]
Pinheiro YT (2026). [PMID: 41632718](https://pubmed.ncbi.nlm.nih.gov/41632718/). *PLoS One*. [Epidemiology / Natural History]
List K (2026). [PMID: 41935205](https://pubmed.ncbi.nlm.nih.gov/41935205/). *J Public Health Policy*. [Review / Meta-Analysis]
Balen SA (2026). [PMID: 41297049](https://pubmed.ncbi.nlm.nih.gov/41297049/). *J Speech Lang Hear Res*. [Basic Science / Preclinical]
Miller AP (2026). [PMID: 41593554](https://pubmed.ncbi.nlm.nih.gov/41593554/). *BMC Public Health*. [Epidemiology / Natural History]
Cope AB (2026). [PMID: 41396701](https://pubmed.ncbi.nlm.nih.gov/41396701/). *Sex Transm Dis*. [Epidemiology / Natural History]
López-Corbeto E (2026). [PMID: 41967336](https://pubmed.ncbi.nlm.nih.gov/41967336/). *Enferm Infecc Microbiol Clin (Engl Ed)*. [Epidemiology / Natural History]
Lassen J (2026). [PMID: 41043122](https://pubmed.ncbi.nlm.nih.gov/41043122/). *Sex Transm Dis*. [Epidemiology / Natural History]
AI-curated news mentioning congenital syphilis
Updated Sep 3, 2026
A study provides molecular and serological evidence of systemic Treponema pallidum infection in wild western chimpanzees, highlighting potential zoonotic implications. This research contributes to understanding the disease's transmission dynamics in wildlife.
A recent case study highlights a multidisciplinary management approach for adult-onset presumed congenital syphilitic keratitis. This research contributes to the understanding of the disease's presentation and management strategies.
A recent study highlights skull osteomyelitis as a rare lytic lesion associated with syphilis. This finding adds to the understanding of syphilis manifestations and may influence clinical approaches.
CDC reports a continued rise in U.S. cases of newborn syphilis, marking the 12th consecutive year of increase. This trend highlights the ongoing public health challenge posed by sexually transmitted infections.
The CDC reports over two million cases of chlamydia, gonorrhea, and syphilis in 2016, marking the highest incidence ever recorded. This alarming trend underscores the urgent need for enhanced prevention efforts.