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secondary syringomyelia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

secondary syringomyelia

MONDO:0020509

Overview

Secondary syringomyelia is a rare medullar disease defined as a development of a fluid-filled cavity or syrinx within the spinal cord due to blockage of CSF circulation (e.g., due to basal archnoiditis, meningeal carcinomatosis, various mass lesions), spinal cord injury (e.g., due to trauma, radiation necrosis, hemorrhage, spinal abscess), spinal dysraphism or intramedullary tumors. It presents with neuropathic pain, numbness, muscular weakness, changes in tone or spasticity or autonomic changes (hyperhidrosis, heart rate or blood pressure instability). Selective loss of pain and temperature with relative preservation of dorsal column function (touch and pressure) are classic findings.

ResearchLimited published research (7 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Syringomyelia; and very common findings: Hyperintensity of MRI T2 signal of the spinal cord. 26 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	8	Dysphonia, Difficulty walking (gait disturbance), Paresthesia

Prognosis

Phenotype severity distribution: 1 always present feature, 1 very common feature, 14 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for secondary syringomyelia.

7 publications have been identified in PubMed for secondary syringomyelia. Research spans Case Report / Case Series (71%) and Review / Meta-Analysis (29%).

Recent Publications

Chan WC (2025). [PMID: 40396800](https://pubmed.ncbi.nlm.nih.gov/40396800/). *Acta Neurol Taiwan*. [Case Report / Case Series]
Wendling D (2025). [PMID: 39894385](https://pubmed.ncbi.nlm.nih.gov/39894385/). *Joint Bone Spine*. [Case Report / Case Series]
Pérez-Bovet J (2025). [PMID: 40955081](https://pubmed.ncbi.nlm.nih.gov/40955081/). *Can J Neurol Sci*. [Case Report / Case Series]
Na CH (2025). [PMID: 40791296](https://pubmed.ncbi.nlm.nih.gov/40791296/). *Brain Spine*. [Case Report / Case Series]
Cheng YH (2024). [PMID: 39216056](https://pubmed.ncbi.nlm.nih.gov/39216056/). *Neurol India*. [Case Report / Case Series]
Zhang W (2024). [PMID: 39435986](https://pubmed.ncbi.nlm.nih.gov/39435986/). *CNS Neurosci Ther*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 5:35 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:99857

GARD

Genetic and Rare Diseases Info Center

GARD:19692

Questions for Your Care Team

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secondary syringomyelia

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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