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anterior cutaneous nerve entrapment syndrome (ACNES) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

anterior cutaneous nerve entrapment syndrome

MONDO:0018873

Also known as:ACNESintercostal nerve syndromerectus abdominis syndrome

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Overview

Anterior cutaneous nerve entrapment syndrome (ACNES) is a chronic neuropathic pain syndrome of the abdominal wall caused by entrapment of anterior cutaneous branches of 7 to 12th intercostal nerves along the lateral border of the anterior rectus abdominis fascia causing severe pain and tenderness of the involved dermatome.

Clinical Trials1 registered

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abdominal pain, Somatic sensory dysfunction, and Impaired tactile sensation; and common findings: Excessive sweating (hyperhidrosis) and Vertigo. 17 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	5	Abdominal pain, Nausea, Anorexia

Diagnosis

Biomarker and diagnostic research for anterior cutaneous nerve entrapment syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 very common features, 2 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Interventions under study include drug therapy. Pipeline includes 1 PHASE4. Research is primarily sponsored by academic and government institutions.

63 publications have been identified in PubMed for anterior cutaneous nerve entrapment syndrome. Research spans Case Report / Case Series (56%), Review / Meta-Analysis (21%), and Clinical Trial Publication (11%).

Research Type	Count	% of Total
Patient case studies	35

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:59 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:51890

GARD

Genetic and Rare Diseases Info Center

GARD:18843

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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anterior cutaneous nerve entrapment syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

anterior cutaneous nerve entrapment syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications