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axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy

MONDO:0016176

Overview

ResearchLimited published research (2 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Impaired vibration sensation in the lower limbs, Progressive peripheral neuropathy, and Demyelinating sensory neuropathy; and common findings: Distal sensory impairment, Distal amyotrophy, Motor axonal neuropathy, and Demyelinating motor neuropathy and others. 19 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	8	Progressive peripheral neuropathy, Demyelinating sensory neuropathy, Motor axonal neuropathy

Diagnosis

Biomarker and diagnostic research for axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 very common features, 7 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy.

2 publications have been identified in PubMed for axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy. Research spans Diagnostic / Biomarker (50%) and Epidemiology / Natural History (50%).

Recent Publications

van Veen R (2026). [PMID: 41819123](https://pubmed.ncbi.nlm.nih.gov/41819123/). *J Peripher Nerv Syst*. [Diagnostic / Biomarker]
Guérémy A (2025). [PMID: 40718906](https://pubmed.ncbi.nlm.nih.gov/40718906/). *European journal of neurology*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 5:36 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:209004

GARD

Genetic and Rare Diseases Info Center

GARD:20415

Questions for Your Care Team

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axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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