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simple cryoglobulinemia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

simple cryoglobulinemia

MONDO:0019606

Also known as:cryoglobulinemia type 1

Overview

Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Purpura, Abnormality of blood and blood-forming tissues, and Cold urticaria; and common findings: Unexplained fevers, Increased circulating IgM level, Acral ulceration, and Distal peripheral sensory neuropathy and others. 55 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	9	Cranial nerve paralysis, Distal peripheral sensory neuropathy, Nerve damage affecting sensation and movement (sensorimotor neuropathy)

Diagnosis

Biomarker and diagnostic research for simple cryoglobulinemia has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 very common features, 12 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for simple cryoglobulinemia.

27 publications have been identified in PubMed for simple cryoglobulinemia. Research spans Case Report / Case Series (59%), Epidemiology / Natural History (15%), and Diagnostic / Biomarker (11%).

Research Type	Count	% of Total
Patient case studies	16	59%

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:91139

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

simple cryoglobulinemia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

A Rare Large-Artery Complication of Cryoglobulinemia: Superior Gluteal Artery Pseudoaneurysm.

simple cryoglobulinemia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

A Rare Large-Artery Complication of Cryoglobulinemia: Superior Gluteal Artery Pseudoaneurysm.