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A rare dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class D (IgD). It is an uncommon primary antibody deficiency. It is most likely an inherited immunodeficiency. It may be caused by decreased or inefficient production of IgD from progenitor B cells without any corresponding decreases in the other isotypes. Most affected persons are asymptomatic and do not appear to be at increased risk for infection.
No clinical trials have been registered for selective IgD deficiency disease.
8 publications have been identified in PubMed for selective IgD deficiency disease. Research spans Basic Science / Preclinical (43%), Review / Meta-Analysis (29%), and Epidemiology / Natural History (29%).
Šlisere B (2026). [PMID: 42000759](https://pubmed.ncbi.nlm.nih.gov/42000759/). *Sci Rep*. [Basic Science / Preclinical]
Justiz Vaillant AA (2026). [PMID: 29763203](https://pubmed.ncbi.nlm.nih.gov/29763203/). *Unknown Journal*. [Review / Meta-Analysis]
Almohammad K (2026). [PMID: 41581071](https://pubmed.ncbi.nlm.nih.gov/41581071/). *Eur J Immunol*. [Basic Science / Preclinical]
Sağun F (2025). [PMID: 40993545](https://pubmed.ncbi.nlm.nih.gov/40993545/). *BMC Immunol*. [Epidemiology / Natural History]
Tejwani V (2025). [PMID: 40682114](https://pubmed.ncbi.nlm.nih.gov/40682114/). *Respir Res*. [Epidemiology / Natural History]
Data assembled from 2 of 12 sources · Last updated Sep 18, 2026, 5:09 PM UTC
Liu JC (2024). [PMID: 39144468](https://pubmed.ncbi.nlm.nih.gov/39144468/). *MedComm (2020)*. [Review / Meta-Analysis]