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selective IgA deficiency disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

selective IgA deficiency disease

MONDO:0001341

Also known as:IgA deficiencySIgADgamma-A-globulin deficiency

Overview

A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders.

Diagnosis

Biomarker and diagnostic research for selective IgA deficiency disease has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for selective IgA deficiency disease.

110 publications have been identified in PubMed for selective IgA deficiency disease. Research spans Epidemiology / Natural History (25%), Case Report / Case Series (22%), and Basic Science / Preclinical (18%).

Research Type	Count	% of Total
Disease patterns and progression	28	25%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 7:31 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:69127

Questions for Your Care Team

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selective IgA deficiency disease

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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