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Sickle Cell Disease — NIH Grants & Funding

Active and recent NIH-funded research on Sickle Cell Disease. Data from NIH RePORTER, last 36 months.

MONDO:0011382

NIH-funded research on Sickle Cell Disease

150

active grants

106

institutions

281

researchers

new in last 12 mo.

$294.0M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(79)

Basic ScienceP01Active

Complications of Hemolysis and Transfusion Therapy

Yazdanbakhsh, Karina·NEW YORK BLOOD CENTER·NEW YORK, NY

$3,043,095 (FY2025)

Sickle Cell Disease — NIH Grants & Funding

Basic Science(79)

Complications of Hemolysis and Transfusion Therapy

The Role of the MBD2-NuRD Complex in Gamma-Globin Gene Silencing

Sickle cell disease molecular pathogenesis and drug therapy

Molecular and Translational Studies in Hematologic Disorders

Modeling Inter-individual Differences to Address Pain of Sickle cell disease (MIDAS)

Advancing a Holistic Understanding of Variability in Lived Experience with Sickle Cell Pain

Molecular Mechanism and Targeting of Chronic Pain in Sickle Cell Disease

Engineering Novel Precision Genome Editing Tools

Immune Pathophysiology of Sickle Cell Disease

Cellular and Molecular Control of Normal and Disordered Erythropoiesis

Translational(29)

KYC, an inhibitor of sickle cell disease's vicious cycle in vaso-occlusive crisis and pain

Efficacy of Hypoxic Red Blood Cells Processed with the Hemanext ONE® System in Patients with Sickle Cell Anemia

HBI-002 to Prevent Vaso-Occlusive Crises in Sickle Cell Disease

A novel glycan-based selectin and complement inhibitor for at-home disease-modifying rescue of pain crisis in sickle cell disease

A precision therapy approach to red cell transfusion for sickle cell disease

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using SGLT2 Inhibitors

Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell Disease

Vascular Targeting Genomic & Genetic Strategies for Acute Chest Syndrome

Complement in the Pathogenesis of Acute Chest Syndrome

Therapeutic Targets in Acute Chest Syndrome

Clinical(81)

Integrative Training Program for Pediatric Sickle Cell Pain

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell disease

Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest Syndrome

Sickle Cell Disease and Cardiovascular Risk- Red Cell Exchange SCD-CARRE

A randomized double-blind, placebo-controlled phase 2 clinical trial of intravenous citrulline for vaso-occlusive crisis in sickle cell disease

Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell disease

Delivering Patient-Facing Evidence-Based Guidelines through mHealth to Adults with Sickle Cell Disease (PF-Guide)

2/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE Trial)

A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects with stable sickle cell disease

Observational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell Disease

Epi / Nat. History(18)

"REAL Answers" (Registry Expansion Analyses to Learn)

Studies of the Natural History of Sickle Cell Disease

SCD REVIVE - Retina to Evaluate Vaso occlusion In the Vasculature of the Eye

Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways

Sex and gender influences on inflammation and pain in sickle cell disease

Mechanisms underlying increased risk of hematological malignancy in sickle cell disease.

Novel therapeutic gene editing to induce fetal hemoglobin for sickle cell disease

Using machine learning to understand cardiopulmonary and renal end organ complications for individuals with SCD

Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study

Insights into Sickle Cell Trait and Sickle Cell Disease

Gene/Cell Therapy(17)

MicroRNA as a Novel Therapeutic Target for Pain in Sickle Cell Disease

Engineering enhanced erythropoiesis for red blood cell disorders

Preclinical and Clinical Studies in Gene Therapy for Sickle Cell Disease

In vivo hematopoietic stem cell genetic modification by viral particles

Base editing and prime editing for sickle cell disease

Targeting ZNF410 for HbF reactivation

Deciphering unintended large gene modifications in gene editing for sickle cell disease

CRISPR-based transistors for high throughput multiplexed monitoring of CRISPR-based editing efficiency for Sickle cell disease

Autoantibody-induced type 1 interferons and RBC alloimmunization in sickle cell disease

Characterizing subphenotypes of long COIVD in patients with sickle cell disease

Biomarker / Dx(13)

[18F]fluoromannitol: A novel imaging agent to delineate osteomyelitis in sickle cell disease

Biomarkers of ischemic brain injury in adults with sickle cell disease

Discovery and validation of single cell biomarkers for clinical outcome in sickle cell disease

Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait

A Study to Evaluate the Effects of fixed dose Flavonoid Isoquercetin on thrombo-inflammatory biomarkers in subjects with stable Sickle Cell Disease

Biomarkers of ischemic risk in adults with sickle cell disease

Microfluidic Impedance Red Cell Assay (MIRCA) for Emerging Pharmacologic and Gene based Therapies for Sickle Cell Disease

The Inflammatory Index as a Biomarker for Pain in Patients with Sickle Cell Disease

Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease

Point of care diagnostic for sickle cell disease

Medical Device(7)

A Sample-to-Answer Point-of-Care Diagnostic for Recently Transfused Sickle Cell Anemia Patients in Low Resource Settings

Affordable Shortwave Infrared Spectroscopy for Stroke Risk Screening in Children with Sickle Cell Disease

Manufacturing and Analytical Validation of the Microfluidic Impedance Red Cell Assay (MIRCA) for Commercial Viability

Endothelialized microfluidic assays for emerging therapies in sickle cell disease

Development of POC system for patient condition and treatment monitoring in Sickle Cell Disease through hypoxia-induced sickling

Using Patient-Centered Guidelines in a Technology Platform to Improve Health Care in Adults with Sickle Cell Disease

Development and Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening.

Other(18)

Sickle Africa Data Coordinating Center

Sickle Cell Disease Pain Analgesia And Integrative Network

Human Specimen Collection to Support Basic and Clinical Research

Phase I study of panobinostat in adults with sickle cell disease: novel approach to recruitment and retention