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sleep-related hypermotor epilepsy (SHE) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

sleep-related hypermotor epilepsy

MONDO:0100631

Also known as:SHEnocturnal frontal lobe epilepsysleep-related hyperkinetic epilepsy

Overview

A focal epilepsy syndrome with characteristic brief motor seizures occurring from sleep. This syndrome was previously known as nocturnal frontal lobe epilepsy, and (when familial) autosomal dominant nocturnal frontal lobe epilepsy. It has both genetic and structural causes. Patients may have hyperkinetic seizures, or seizures with asymmetric dystonic/tonic motor features. The term sleep-related hyperkinetic epilepsy is to be used when patients have hyperkinetic seizures alone.

Diagnosis

Biomarker and diagnostic research for sleep-related hypermotor epilepsy has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for sleep-related hypermotor epilepsy.

44 publications have been identified in PubMed for sleep-related hypermotor epilepsy. Research spans Case Report / Case Series (30%), Basic Science / Preclinical (23%), and Review / Meta-Analysis (20%).

Research Type	Count	% of Total
Patient case studies	13	30%

Data assembled from 2 of 12 sources · Last updated Sep 18, 2026, 12:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

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sleep-related hypermotor epilepsy

Overview

Diagnosis

Research Landscape

Medical References

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Questions for Your Care Team

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