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sporadic adult-onset ataxia of unknown etiology (SAOA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

sporadic adult-onset ataxia of unknown etiology

MONDO:0016591

Also known as:SAOAidiopathic late-onset cerebellar ataxia

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Overview

Sporadic adult-onset ataxia of unknown etiology describes a group of non-hereditary degenerative ataxias characterized by a slowly progressive cerebellar syndrome (with ataxia of stance and gait, upper limb dysmetria and intention tremor, ataxic speech, and oculomotor abnormalities), presenting in adulthood (at around 50 years of age), that is not due to a known cause. Extracerebellar symptoms (e.g., decreased vibration sense and absent or decreased ankle reflexes), polyneuropathy and mild autonomic dysfunction may also be present. Mild cognitive impairment has also rarely been reported.

Clinical Trials1 registered · 1 recruiting

ResearchLimited published research (7 articles)

Diagnosis

Biomarker and diagnostic research for sporadic adult-onset ataxia of unknown etiology has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

7 publications have been identified in PubMed for sporadic adult-onset ataxia of unknown etiology. Research spans Diagnostic / Biomarker (57%) and Review / Meta-Analysis (43%).

Recent Publications

Lee JS (2026). [PMID: 41520408](https://pubmed.ncbi.nlm.nih.gov/41520408/). *Parkinsonism Relat Disord*. [Diagnostic / Biomarker]
Pons NC (2026). [PMID: 42090775](https://pubmed.ncbi.nlm.nih.gov/42090775/). *J Neurol Sci*. [Diagnostic / Biomarker]
Novis LE (2025). [PMID: 39920364](https://pubmed.ncbi.nlm.nih.gov/39920364/). *Cerebellum*. [Review / Meta-Analysis]
Coulette S (2025). [PMID: 40556471](https://pubmed.ncbi.nlm.nih.gov/40556471/). *Eur J Neurol*. [Diagnostic / Biomarker]
Saeed U (2025). [PMID: 40291849](https://pubmed.ncbi.nlm.nih.gov/40291849/). *Front Neurol*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 17, 2026, 8:58 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:247234

GARD

Genetic and Rare Diseases Info Center

GARD:20654

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
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sporadic adult-onset ataxia of unknown etiology

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team