T-cell immunodeficiency with epidermodysplasia verruciformis is a rare primary immunodeficiency that affects the immune system. People with this condition have a normal overall count of T-cells, but these cells do not work properly. The impaired T-cell receptor (TCR) signaling means that the body does not respond adequately to infections. This condition usually presents in childhood. A key feature is an increased susceptibility to human papillomavirus infections, which leads to flat, wart-like lesions on the skin. In some cases, there have also been reports of Burkitt lymphoma. The abnormal immune response is further shown by a low number of naive T-cells and an exhaustion phenotype in memory T-cells.

The symptoms often include widespread, flat, wart-like skin lesions due to human papillomavirus infection. In some cases, there may also be reports of conditions like Burkitt lymphoma. The skin changes along with signs of immune system dysfunction are key aspects associated with this condition.

This condition is related to problems with T-cell function. Although the total count of T-cells is normal, there is an impairment in T-cell receptor signaling leading to abnormal immune responses. It is also known as T-cell immunodeficiency due to RHOH deficiency, which suggests a possible genetic role; however, detailed genetic information is not provided in the available sources.