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testicular yolk sac tumor - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

testicular yolk sac tumor

MONDO:0003402

Also known as:testicular yolk Sac neoplasmtestis yolk sac tumortestis yolk sac tumour

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Overview

A non-seminomatous malignant germ cell tumor arising from the testis. It affects infants, young children, and postpubertal males. It is the most frequently seen testicular neoplasm during childhood. The vast majority of patients present with an asymptomatic scrotal mass. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). It metastasizes to distant anatomic sites. Prognostic factors relate to the clinical stage and the degree of AFP elevation.

Clinical Trials10 registered · 4 recruiting

Diagnosis

Biomarker and diagnostic research for testicular yolk sac tumor has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

10 clinical trials registered, 4 recruiting. Interventions under study include gene therapy, drug therapy, procedural interventions, and biologic therapy. Pipeline includes 2 PHASE3, 1 PHASE2, 6 PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07148050](https://clinicaltrials.gov/study/NCT07148050)

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 7:07 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 10 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Patient case studies	18	31%
Laboratory research	16	28%
Research summaries	11	19%
Testing and diagnosis research	7	12%
Disease patterns and progression	2	3%
New treatment approaches	2	3%
Other research	1	2%
Clinical study results	1	2%

Kisho

testicular yolk sac tumor

Overview

Diagnosis

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Intracardiac Metastasis From a Testicular Yolk Sac Tumor With Brain and Pulmonary Involvement: A Multimodality Management Case Report.

testicular yolk sac tumor

Overview

Diagnosis

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Intracardiac Metastasis From a Testicular Yolk Sac Tumor With Brain and Pulmonary Involvement: A Multimodality Management Case Report.