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Trisomy — NIH Grants & Funding

Active and recent NIH-funded research on Trisomy. Data from NIH RePORTER, last 36 months.

MONDO:0700065

NIH-funded research on Trisomy

active grants

institutions

122

researchers

new in last 12 mo.

$102.9M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(58)

Basic ScienceRF1Active

Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids

Thunemann, Martin et al.·BOSTON UNIVERSITY MEDICAL CAMPUS·BOSTON, MA

$2,357,335 (FY2024)

Trisomy — NIH Grants & Funding

Basic Science(58)

Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids

Brain Development in Down Syndrome during Fetal and Early Postnatal Ages

Prenatal Treatment of Down Syndrome to Improve Brain Development and Neurocognition

Modifiers of Down Syndrome Co-occurring Phenotypes

Transposable Element Mobilization and Disrupted Translational Machinery in Down Syndrome

Transitions in the acquisition of language in kids with Down Syndrome

Multidimensional investigation of auditory dysfunction in Down syndrome

Novel computational strategies to deconvolute co-occurring conditions in Down syndrome

Why do Down Syndrome patients have high risk of Hirschsprung disease?

Septhohippocamal connectome dysfunction in Down syndrome associated with Alzheimer’s disease pathophysiology

Translational(5)

DLK1 as a novel target for Down syndrome myeloid leukemia

Nicotinamide Adenine Dinucleotide Augmentation to Prevent or Reverse the Progression of Alzheimer's Disease in People with Down Syndrome

Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome

Enhancing treatments for myeloid leukemia associated with Down syndrome

Translational Epigenetics with XIST: Silencing Trisomy in Human Organoid and Mouse Models of Down Syndrome

Clinical(13)

Mechanistic investigation of therapies for Down Syndrome Regression Disorder

The Impact of Weight Loss on Alzheimer's Disease Risk in Adults with Down Syndrome

Behavior Measure for Children and Adolescents with Down Syndrome

Lifestyle and Alzheimer's Disease In Down Syndrome

Preventing Fatal Infections in Children with Down Syndrome During Treatment for Acute Lymphoblastic Leukemia

Role of congenital heart defects in motor skills and language acquisition of infants with Down syndrome

Heterogeneous genetics effects and mediation in Alzheimer's disease

Gastrointestinal Dysfunction in Down Syndrome

Characterizing Language and Motor Development of Racially/Ethnically Diverse Infants and Toddlers with Down Syndrome

Tongue maturation deficits in a mouse model of Down syndrome

Epi / Nat. History(2)

Obesity Prevention Targets for Down Syndrome

CArdiometabolic riSk and Comorbidities in Adults with Down syndrome- Electronic Health Record Examination (CASCADE)

Biomarker / Dx(4)

Sleep Spindle Dynamics as a Clinical Biomarker of Aging, Alzheimer's Disease, and Trisomy 21

Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)

Infant arousal as a predictor of functional outcomes in Down syndrome (DS)

Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.

Other(6)

The INCLUDE Data Coordinating Center

Trisomy 21 Model Atlas

Molecular regulators of GABAergic systems that underlie comorbidities in Down syndrome

Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairments with aging

Institutional Career Development Core

T21RS Meeting June 2024 Rome, Italy