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Trisomy — NIH Grants & Funding

Active and recent NIH-funded research on Trisomy. Data from NIH RePORTER, last 36 months.

MONDO:0700065

Looking for specific grants? The Recent Research tab lets you search and filter by topic.

Funding Landscape

Trisomy has a robust NIH research funding landscape with 88 funded grants and $102.9M in total funding over the period.

88funded grants from NIH

Portfolio: $58.2MCumulative: $102.9M77 active11 completed122 PIs57 institutions

+98% YoY(FY2024 vs FY2025)

22 new grants started in the last 12 months.

By Research Theme

Basic Science

Clinical

Translational

Biomarker / Dx

Epi / Nat. History

6 additional grants classified as “Other” (multi-disciplinary, infrastructure, etc.).

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$1.1M

FY22

$5.6M

FY23

$31.0M

FY24

$61.2M

FY25

$4.1M

FY26

By Funding Mechanism

R01

R21

RF1

F30

F31

F32

Funding Gap Analysis

Cross-referencing NIH grants against published research and clinical trials to identify funding-evidence gaps for Trisomy. Strongest funded area: Basic Science. Largest gap: Translational / Drug Development.

Translational / Drug DevelopmentFunded, Few Publications

5 funded grants in Translational / Drug Development but only 2 related publications found for trisomy. This may indicate early-stage research that hasn't yet produced published results.

Adjacent Research(59 grants)

These grants mention Trisomy as part of broader research but are not primarily focused on this disease. They are not included in the funding totals above.

Other(59)

OtherU24Active

The INCLUDE Project Down Syndrome Biorepository (DS-Biorepository)

Espinosa, Joaquin et al.·UNIVERSITY OF COLORADO DENVER·Aurora, CO

$5,325,989 (FY2025)

NIH RePORTER

OtherP30Active

The Alzheimer's Disease Research Center at the University of California, Irvine

Grill, Joshua et al.·UNIVERSITY OF CALIFORNIA-IRVINE·IRVINE, CA

$4,325,343 (FY2025)

NIH RePORTER

OtherU01Active

Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)

HANDEN, BENJAMIN et al.·UNIVERSITY OF WISCONSIN-MADISON·MADISON, WI

$2,800,027 (FY2024)

NIH RePORTER

OtherU01Active

Human Trisome Project - Latin America Network

Espinosa, Joaquin et al.·UNIVERSITY OF COLORADO DENVER·Aurora, CO

$2,693,143 (FY2024)

NIH RePORTER

OtherR33Completed

Clinical trials to prevent Alzheimer's Disease in Down Syndrome

Rafii, Michael·UNIVERSITY OF SOUTHERN CALIFORNIA·Los Angeles, CA

$2,284,142 (FY2024)

NIH RePORTER

OtherR24Active

Human Immune System Humanized Modeling of Down Syndrome Immune Responses to Pluripotent Stem Cells

Brown, Matthew·UNIVERSITY OF WISCONSIN-MADISON·MADISON, WI

$1,488,578 (FY2025)

NIH RePORTER

OtherRF1Active

Establishing an Alzheimer’s disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes

BETTHAUSER, TOBEY et al.·UNIVERSITY OF WISCONSIN-MADISON·MADISON, WI

$1,346,873 (FY2025)

NIH RePORTER

OtherRF1Active

A humanized monoclonal FSH antibody for Alzheimer's Disease and co-occurring health conditions in Down Syndrome

Goosens, Ki et al.·ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI·NEW YORK, NY

$1,257,163 (FY2025)

NIH RePORTER

OtherR33Completed

Evaluating Assessment and Medication Treatment of ADHD in Children with Down Syndrome

Esbensen, Anna et al.·CINCINNATI CHILDRENS HOSP MED CTR·CINCINNATI, OH

$1,080,279 (FY2024)

NIH RePORTER

OtherR61Active

Home Grown: A family-based lifestyle intervention to support healthy development of young children with Down syndrome

Willis, Erik·UNIV OF NORTH CAROLINA CHAPEL HILL·CHAPEL HILL, NC

$1,017,548 (FY2025)

NIH RePORTER

NIH Grants & Funding for Trisomy | Kisho | Kisho

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Trisomy — NIH Grants & Funding

Funding Landscape

By Research Theme

Funding by Fiscal Year

By Funding Mechanism

Funding Gap Analysis

Adjacent Research(59 grants)

Other(59)

The INCLUDE Project Down Syndrome Biorepository (DS-Biorepository)

The Alzheimer's Disease Research Center at the University of California, Irvine

Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)

Human Trisome Project - Latin America Network

Clinical trials to prevent Alzheimer's Disease in Down Syndrome

Human Immune System Humanized Modeling of Down Syndrome Immune Responses to Pluripotent Stem Cells

Establishing an Alzheimer’s disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes

A humanized monoclonal FSH antibody for Alzheimer's Disease and co-occurring health conditions in Down Syndrome

Evaluating Assessment and Medication Treatment of ADHD in Children with Down Syndrome

Home Grown: A family-based lifestyle intervention to support healthy development of young children with Down syndrome

Top Funded Institutions

Top Principal Investigators