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Visceral calciphylaxis is a rare, life-threatening, non-inflammatory vasculopathy disorder characterized by diffuse precipitation of calcium in viscera (mainly in the heart or lungs, but also in the stomach or kidneys) leading to fibrosis and thrombosis, which eventually cause necrotic ulcerations of the tissue. Patients may present with dyspnea, cough and respiratory failure or acute heart block and subsequent sudden cardiac death, depending on the affected organ. The disease mainly affects patients on dialysis or patients having undergone renal transplantation.
No clinical trials have been registered for visceral calciphylaxis.
8 publications have been identified in PubMed for visceral calciphylaxis. Research spans Case Report / Case Series (63%) and Review / Meta-Analysis (38%).
Lim WT (2025). [PMID: 40303896](https://pubmed.ncbi.nlm.nih.gov/40303896/). *Case Rep Nephrol Dial*. [Case Report / Case Series]
Johnson A (2025). [PMID: 40062960](https://pubmed.ncbi.nlm.nih.gov/40062960/). *Am J Forensic Med Pathol*. [Case Report / Case Series]
Vaz J (2025). [PMID: 39837779](https://pubmed.ncbi.nlm.nih.gov/39837779/). *Hemodial Int*. [Case Report / Case Series]
Ito N (2025). [PMID: 40467508](https://pubmed.ncbi.nlm.nih.gov/40467508/). *Intern Med*. [Case Report / Case Series]
Wu D (2025). [PMID: 40097288](https://pubmed.ncbi.nlm.nih.gov/40097288/). *J Mol Cell Biol*. [Review / Meta-Analysis]
Pillai V (2025). [PMID: 41346420](https://pubmed.ncbi.nlm.nih.gov/41346420/). *Cureus*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:31 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
D Shirsat P (2025). [PMID: 41472909](https://pubmed.ncbi.nlm.nih.gov/41472909/). *Case Rep Nephrol*. [Review / Meta-Analysis]
Ortonne N (2024). [PMID: 39368935](https://pubmed.ncbi.nlm.nih.gov/39368935/). *Ann Pathol*. [Review / Meta-Analysis]
AI-curated news mentioning visceral calciphylaxis
Updated Aug 10, 2026
A systematic review highlights the pathomechanisms and risk factors associated with calciphylaxis in chronic kidney disease, focusing on calcific uremic arteriolopathy. This research provides insights that could inform future therapeutic strategies.
A case study highlights the diagnostic challenges of early calciphylaxis in a patient with end-stage renal disease and sarcoidosis. The findings emphasize the need for careful wound management and awareness of calciphylaxis symptoms in similar patients.