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A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, seizures, and coma. It may follow a viral illness or mycoplasma pneumoniae infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)
Biomarker and diagnostic research for acute necrotizing encephalitis has been reported in the published literature.
No clinical trials have been registered for acute necrotizing encephalitis.
111 publications have been identified in PubMed for acute necrotizing encephalitis. Research spans Case Report / Case Series (40%), Epidemiology / Natural History (22%), and Review / Meta-Analysis (9%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 44 | 40% |
Data assembled from 2 of 12 sources · Last updated Sep 19, 2026, 1:58 AM UTC
Genetic and Rare Diseases Info Center
Common questions about acute necrotizing encephalitis
Disease patterns and progression
24 |
22% |
Research summaries | 10 | 9% |
Other research | 8 | 7% |
Laboratory research | 8 | 7% |
Clinical study results | 6 | 5% |
New treatment approaches | 6 | 5% |
Testing and diagnosis research | 5 | 5% |
Shimohata T (2026). [PMID: 42156048](https://pubmed.ncbi.nlm.nih.gov/42156048/). *Brain Nerve*. [Review / Meta-Analysis]
Wang W (2026). [PMID: 41928270](https://pubmed.ncbi.nlm.nih.gov/41928270/). *Virol J*. [Clinical Trial Publication]
Yan Y (2026). [PMID: 42143224](https://pubmed.ncbi.nlm.nih.gov/42143224/). *BMC Infect Dis*. [Basic Science / Preclinical]
Fan C (2026). [PMID: 41655631](https://pubmed.ncbi.nlm.nih.gov/41655631/). *Translational research : the journal of laboratory and clinical medicine*. [Gene Therapy / Novel Therapeutics]
Adeleke AA (2026). [PMID: 41869187](https://pubmed.ncbi.nlm.nih.gov/41869187/). *Cureus*. [Case Report / Case Series]
Desgraupes S (2026). [PMID: 41651846](https://pubmed.ncbi.nlm.nih.gov/41651846/). *Nature communications*. [Case Report / Case Series]
Manikya S (2026). [PMID: 41895130](https://pubmed.ncbi.nlm.nih.gov/41895130/). *Pediatr Neurol*. [Other]
S A (2026). [PMID: 42114927](https://pubmed.ncbi.nlm.nih.gov/42114927/). *BMJ Case Rep*. [Case Report / Case Series]
Bhanudeep S (2026). [PMID: 41622401](https://pubmed.ncbi.nlm.nih.gov/41622401/). *Indian journal of pediatrics*. [Case Report / Case Series]
Wang CH (2026). [PMID: 41794616](https://pubmed.ncbi.nlm.nih.gov/41794616/). *Anales de pediatria*. [Epidemiology / Natural History]
AI-curated news mentioning acute necrotizing encephalitis
Updated Jul 22, 2026
A scoping review of 83 cases highlights the clinical features and outcomes of influenza-associated encephalopathy, encephalitis, and acute necrotizing encephalitis in adults. This research provides valuable insights into the rare neurological complications linked to influenza infections.