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tick-borne encephalitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

tick-borne encephalitis

MONDO:0017572

Also known as:Far Eastern TBERussian spring-summer encephalitisSiberian tick-borne encephalitis

Find Clinical TrialsTrials

Overview

Tick-borne encephalitis is caused by an arbovirus of the Flaviviridae family (tick-borne encephalitis virus, TBEV), transmitted principally by the bite of the Ixodes ricinus tick. The symptomology is biphasic, with the initial phase being associated with a flu-like illness and the second phase (occurring in less than 10% of patients) with symptoms of meningitis or, more rarely, meningoencephalitis.

Clinical Trials6 registered · 3 recruiting

ResearchLimited published research (5 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: CSF pleocytosis; and common findings: Low white blood cell count (decreased total leukocyte count), Nausea, Anorexia, and Headache and others. 63 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	18	Headache, Fatigue, Atypical behavior

Prognosis

Phenotype severity distribution: 1 very common feature, 9 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 3 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE3, 1 PHASE1, 1 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07377253](https://clinicaltrials.gov/study/NCT07377253)

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:297

GARD

Genetic and Rare Diseases Info Center

GARD:5216

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

tick-borne encephalitis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Serological Evidence of Tick-Borne Encephalitis Virus (TBEV) Exposure Among Hospitalized Neurological Patients in Israel, 2010-2019.

Extraneurological Presentations of Tick-Borne Encephalitis Virus: A Rare Case of TBEV-Associated Myocarditis With Fever and Bicytopenia and a Systematic Literature Review.

A rare case of breakthrough tick-borne encephalitis in early adolescence after vaccination with four doses of TBE vaccine.

tick-borne encephalitis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Serological Evidence of Tick-Borne Encephalitis Virus (TBEV) Exposure Among Hospitalized Neurological Patients in Israel, 2010-2019.

Extraneurological Presentations of Tick-Borne Encephalitis Virus: A Rare Case of TBEV-Associated Myocarditis With Fever and Bicytopenia and a Systematic Literature Review.

A rare case of breakthrough tick-borne encephalitis in early adolescence after vaccination with four doses of TBE vaccine.