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Acute opioid poisoning is a rare intoxication with opioids, a large group of alkaloid analgesics, mainly characterized by miosis (pinpoint pupil), respiratory depression (bradypnea/apnea) and central nervous system depression (sedation or coma). Other manifestations include hypotension, reduced bowel motility, hypothermia and hypoglycemia. Naloxone, a competitive inhibitor of the mu-opioid receptor, is a potent antagonist and is used as the antidote for opioid intoxication.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for acute opioid poisoning.
1 publication has been identified in PubMed for acute opioid poisoning. Research spans Review / Meta-Analysis (100%).
Nemati A (2025). [PMID: 41023783](https://pubmed.ncbi.nlm.nih.gov/41023783/). *International journal of emergency medicine*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 3:50 PM UTC
European rare disease database
Common questions about acute opioid poisoning