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alpha-heavy chain disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

alpha-heavy chain disease

MONDO:0015045

Also known as:Alpha-HCDIPSIDImmunoproliferative small intestinal disease

Overview

Alpha-heavy chain disease (alpha-HCD) is a type of HCD characterized by the production of incomplete monoclonal alpha-heavy chains without associated light chains. Alpha-HCD is considered to be a subtype of immunoproliferative small intestinal disease (IPSID). The clinical presentation includes chronic diarrhea with evidence of malabsorption.

ResearchLimited published research (5 articles)

Diagnosis

Biomarker and diagnostic research for alpha-heavy chain disease has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for alpha-heavy chain disease.

5 publications have been identified in PubMed for alpha-heavy chain disease. Research spans Case Report / Case Series (80%) and Diagnostic / Biomarker (20%).

Recent Publications

Ahmed M (2026). [PMID: 42170394](https://pubmed.ncbi.nlm.nih.gov/42170394/). *Pak J Med Sci*. [Case Report / Case Series]
Ahmadinejad M (2025). [PMID: 41541135](https://pubmed.ncbi.nlm.nih.gov/41541135/). *International journal of surgery case reports*. [Case Report / Case Series]
Schroeter CB (2024). [PMID: 38888758](https://pubmed.ncbi.nlm.nih.gov/38888758/). *Acta neuropathologica*. [Diagnostic / Biomarker]
Tang W (2024). [PMID: 39176219](https://pubmed.ncbi.nlm.nih.gov/39176219/). *ACG case reports journal*. [Case Report / Case Series]
Ismail M (2024). [PMID: 39006573](https://pubmed.ncbi.nlm.nih.gov/39006573/). *Cureus*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 5:46 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:100025

GARD

Genetic and Rare Diseases Info Center

GARD:19742

Questions for Your Care Team

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alpha-heavy chain disease

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team