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Gamma-heavy chain disease (gamma-HCD) is a type of HCD characterized by the production of incomplete monoclonal gamma-heavy chains without associated light chains. The clinical presentation most commonly resembles that of patients with systemic lymphoproliferative/autoimmune diseases.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for gamma-heavy chain disease.
6 publications have been identified in PubMed for gamma-heavy chain disease. Research spans Case Report / Case Series (100%).
George GV (2026). [PMID: 40611654](https://pubmed.ncbi.nlm.nih.gov/40611654/). *International journal of surgical pathology*. [Case Report / Case Series]
El Boutahiri I (2026). [PMID: 41668820](https://pubmed.ncbi.nlm.nih.gov/41668820/). *European journal of case reports in internal medicine*. [Case Report / Case Series]
Cicerchia C (2025). [PMID: 40838430](https://pubmed.ncbi.nlm.nih.gov/40838430/). *Immunotherapy*. [Case Report / Case Series]
Dodos K (2025). [PMID: 41659142](https://pubmed.ncbi.nlm.nih.gov/41659142/). *Acta medica Lituanica*. [Case Report / Case Series]
Al-Sawajneh S (2025). [PMID: 40634181](https://pubmed.ncbi.nlm.nih.gov/40634181/). *Clinical lymphoma, myeloma & leukemia*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 7:50 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center