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argyria - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

argyria

MONDO:0018952

Also known as:Silver staining

Overview

Argyria is a rare dermatosis, which can be either localized or systemic, that occurs after prolonged contact and absorption of silver containing compounds over a period of years and that is characterized by irreversible blue-gray to gray-black staining of skin, fingernails and/or mucous membranes, most evident on sun exposed areas of the skin. Silver exposure is usually occupational but may also occur through dental amalgams, the ingestion of colloidal silver, acupuncture needles, orthopedic implants and topical medications (such as silver sulfadiazine).

Diagnosis

Biomarker and diagnostic research for argyria has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for argyria.

145 publications have been identified in PubMed for argyria. Research spans Basic Science / Preclinical (63%), Case Report / Case Series (16%), and Diagnostic / Biomarker (8%).

Research Type	Count	% of Total
Laboratory research	91	63%

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:11 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:60014

GARD

Genetic and Rare Diseases Info Center

GARD:18856

Questions for Your Care Team

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argyria

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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