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lead poisoning - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

lead poisoning

MONDO:0018019

Also known as:Lead intoxicationplumbismsaturnism

Find Clinical TrialsTrials

Overview

5 ug/dL) is reported to lead to irreversible effects such as loss of cognition, shortening of attention span, alteration of behavior, dyslexia, attention deficit disorder, hypertension, renal impairment, immunotoxicity and toxicity to the reproductive organs.

Treatments1 FDA approved

Clinical Trials2 registered

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Hypertension, Vomiting, Nausea, and Constipation and others; and sometimes findings: Renal tubular dysfunction, Delayed eruption of teeth, Atypical behavior, and Depression and others. 60 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	16	Fatigue, Atypical behavior, Depression

Diagnosis

Biomarker and diagnostic research for lead poisoning has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for lead poisoning, including SUCCIMER (CHEMET, approved 1991).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Phenotype severity distribution: 8 common features.

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered. Interventions under study include other interventions. Pipeline includes 1 NA. Research is sponsored by a mix of industry and academic institutions.

261 publications have been identified in PubMed for lead poisoning. Research spans Epidemiology / Natural History (42%), Basic Science / Preclinical (19%), and Case Report / Case Series (16%).

Research Type	Count	% of Total
Disease patterns and progression	110	42%

Data assembled from 6 of 12 sources · Last updated Sep 18, 2026, 3:56 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:330015

GARD

Genetic and Rare Diseases Info Center

GARD:21503

Questions for Your Care Team

→What are the benefits and potential side effects of CHEMET for managing lead poisoning?
→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

lead poisoning

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

CDC investigation: Blood lead levels higher after switch to Flint River water - Press Release

lead poisoning

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

CDC investigation: Blood lead levels higher after switch to Flint River water - Press Release