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Centrifugal lipodystrophy is a rare, acquired, localized lipodistrophy characterized by single or, occasionally, multiple, centrifugally progressive, asymptomatic to sometimes mildly tender, hypopigmented, lipoatrophic skin depressions with weakly erymatheous inflammatory borders, typically associated with regional ipsilateral lymph nodes swelling. Lesions typically occur on lower trunk (in particular groin and abdomen region), followed by upper trunk (axilla and neighboring regions) and, rarely, neck and head. It is usually not associated with systemic disease and is typically self-resolving.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for centrifugal lipodystrophy.
3 publications have been identified in PubMed for centrifugal lipodystrophy. Research spans Basic Science / Preclinical (67%) and Review / Meta-Analysis (33%).
Pliszka M (2025). [PMID: 40565151](https://pubmed.ncbi.nlm.nih.gov/40565151/). *International journal of molecular sciences*. [Review / Meta-Analysis]
Horikoshi N (2025). [PMID: 39929866](https://pubmed.ncbi.nlm.nih.gov/39929866/). *Nature communications*. [Basic Science / Preclinical]
Song Y (2024). [PMID: 38744820](https://pubmed.ncbi.nlm.nih.gov/38744820/). *Nature communications*. [Basic Science / Preclinical]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:54 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center