A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones.
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation for chronic primary adrenal insufficiency is limited primarily because it affects a small population, making systematic clinical studies challenging. Additionally, the genetic basis was only recently identified, and ongoing clinical characterization is required to better understand the condition and its manifestations.
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Currently, there are 7 active clinical trials focused on chronic primary adrenal insufficiency. These trials may explore various treatment options and management strategies. For more information on these studies, you can visit ClinicalTrials.gov and search for chronic primary adrenal insufficiency: https://clinicaltrials.gov/search?cond=chronic%20primary%20adrenal%20insufficiency.
Actionable guidance for navigating care for chronic primary adrenal insufficiency
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the chronic primary adrenal insufficiency community
Helpful links for rare disease information and support
The documentation for chronic primary adrenal insufficiency is limited primarily because it affects a small population, making systematic clinical studies challenging. Additionally, the genetic basis was only recently identified, and ongoing clinical characterization is required to better understand the condition and its manifestations.
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Currently, there are 7 active clinical trials focused on chronic primary adrenal insufficiency. These trials may explore various treatment options and management strategies. For more information on these studies, you can visit ClinicalTrials.gov and search for chronic primary adrenal insufficiency: https://clinicaltrials.gov/search?cond=chronic%20primary%20adrenal%20insufficiency.
Actionable guidance for navigating care for chronic primary adrenal insufficiency
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the chronic primary adrenal insufficiency community
Helpful links for rare disease information and support
The documentation for chronic primary adrenal insufficiency is limited primarily because it affects a small population, making systematic clinical studies challenging. Additionally, the genetic basis was only recently identified, and ongoing clinical characterization is required to better understand the condition and its manifestations.
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Currently, there are 7 active clinical trials focused on chronic primary adrenal insufficiency. These trials may explore various treatment options and management strategies. For more information on these studies, you can visit ClinicalTrials.gov and search for chronic primary adrenal insufficiency: https://clinicaltrials.gov/search?cond=chronic%20primary%20adrenal%20insufficiency.
Actionable guidance for navigating care for chronic primary adrenal insufficiency
To navigate chronic primary adrenal insufficiency effectively, consider consulting with an endocrinologist who specializes in adrenal disorders. Engaging with patient organizations such as the National Adrenal Diseases Foundation (NADF) at https://nadf.us or the Canadian Addison Society at https://addisonsociety.ca can provide valuable resources and support. Additionally, exploring opportunities for participation in patient registries or natural history studies may enhance your understanding of the condition. Genetic counseling should also be considered due to the known genetic factors.
Consider asking your healthcare providers these condition-specific questions
Connect with organizations supporting the chronic primary adrenal insufficiency community
Helpful links for rare disease information and support
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Feb 10, 2026
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
Consider asking your healthcare providers these condition-specific questions
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
3 peer-reviewed sources from PubMed
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 17 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.