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Complex regional pain syndrome (CRPS) is defined in the packet as a chronic pain syndrome characterized by disproportionate spontaneous or stimulus-induced pain, accompanied by a variable mix of autonomic and motor disorders. Features named in the definition include swelling, allodynia, and disturbances of skin blood supply and trophic changes. The definition states that it most often affects one of the arms, legs, hands or feet and usually occurs after an injury or trauma to that limb. The packet lists two subtypes, complex regional pain syndrome type 1 and complex regional pain syndrome type 2. The packet does not supply a prevalence estimate.
The packet lists twelve phenotypes with HPO frequency language. Limb pain is annotated as very frequent (80-99%). The following are annotated as frequent (30-79%): dry skin, somatic sensory dysfunction, involuntary movements, slow-growing nails, pedal edema, edema of the upper limbs, erythema, trophic changes related to pain, allodynia, dysesthesia and abnormality of hair growth. No age-of-onset category is recorded.
The packet lists no genes for this condition and records no inheritance pattern or molecular mechanism, so the genetic basis is not characterized here. The disease definition notes that the condition usually occurs after an injury or trauma to the affected limb.
The packet does not contain diagnostic-methods or expert-review diagnosis text, so specific tests or criteria are not certified here. No newborn-screening information is recorded.
Treatment coverage is not certified in this packet. It contains no foundational-therapy records, no expert-review management text and no verified FDA-approved treatment records for this condition, which does not indicate that none exist. The packet does record regulatory designations of several investigational products for this indication, but such designations are not approvals and do not indicate availability.
60 trials found
Prognosis is not certified in this packet, which contains no natural-history text or clinical description from expert review.
According to ClinicalTrials.gov records in the packet, active studies related to this condition are present, including recruiting studies. Listed titles include phase 3 studies of intravenous neridronate in CRPS type 1, a study of conservative treatment, and a transcranial magnetic stimulation study. The packet describes the interventions studied as drug therapy, medical devices, procedural interventions and other interventions, from a mix of industry and academic sponsors, with no gene therapy trials flagged. Its publication digest indicates a literature dominated by reviews and meta-analyses. Active clinical trials for this condition are listed on ClinicalTrials.gov.
Data assembled from 6 of 12 sources · Last updated Nov 3, 2026, 11:44 PM UTC
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AI-curated news mentioning complex regional pain syndrome
Updated Sep 17, 2026
Recent research using ultra-high field functional MRI has identified specific activation patterns in the hypothalamus and brainstem in response to heat stimuli in patients with complex regional pain syndrome. This study enhances understanding of the neural mechanisms underlying this condition.
A study published in PubMed highlights the implementation of a fast-track pathway for complex regional pain syndrome, examining its impact on referral delays and one-year clinical outcomes. This research provides insights into improving patient management for this condition.
A nationwide cohort study investigates the relationship between income dynamics and the risk of developing complex regional pain syndrome. The findings contribute to understanding socioeconomic factors influencing this condition.