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A malignant germ cell tumor arising in the central nervous system. It is characterized by the presence of primitive, large malignant germ cells and lymphocytes.
Biomarker and diagnostic research for germinoma has been reported in the published literature.
9 clinical trials registered, 5 recruiting. Interventions under study include procedural interventions, drug therapy, and other interventions. Pipeline includes 1 PHASE3, 2 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03158064](https://clinicaltrials.gov/study/NCT03158064) |
Data assembled from 3 of 12 sources · Last updated Oct 4, 2026, 3:01 AM UTC
Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors |
PHASE2 |
Memorial Sloan Kettering Cancer Center |
ACTIVE_NOT_RECRUITING |
[NCT07218913](https://clinicaltrials.gov/study/NCT07218913) | Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors | PHASE1 | City of Hope Medical Center | RECRUITING |
[NCT05982691](https://clinicaltrials.gov/study/NCT05982691) | Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors | — | National Cancer Center, Korea | RECRUITING |
[NCT02375204](https://clinicaltrials.gov/study/NCT02375204) | Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors | PHASE3 | Alliance for Clinical Trials in Oncology | ACTIVE_NOT_RECRUITING |
[NCT06368817](https://clinicaltrials.gov/study/NCT06368817) | A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma | PHASE2 | Children's Oncology Group | RECRUITING |
250 publications have been identified in PubMed for germinoma. Research spans Case Report / Case Series (34%), Review / Meta-Analysis (18%), and Epidemiology / Natural History (17%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 84 | 34% |
Research summaries | 44 | 18% |
Disease patterns and progression | 42 | 17% |
Laboratory research | 35 | 14% |
Clinical study results | 24 | 10% |
Testing and diagnosis research | 19 | 8% |
Other research | 1 | 0% |
New treatment approaches | 1 | 0% |
Wu Z (2026). [PMID: 41485106](https://pubmed.ncbi.nlm.nih.gov/41485106/). *J Natl Cancer Inst*. [Clinical Trial Publication]
Capdevila P (2026). [PMID: 41083654](https://pubmed.ncbi.nlm.nih.gov/41083654/). *Clin Transl Oncol*. [Epidemiology / Natural History]
Yokota K (2026). [PMID: 42158165](https://pubmed.ncbi.nlm.nih.gov/42158165/). *JCEM Case Rep*. [Case Report / Case Series]
Poon SWY (2026). [PMID: 41074639](https://pubmed.ncbi.nlm.nih.gov/41074639/). *Pediatric blood & cancer*. [Clinical Trial Publication]
Saliba A (2026). [PMID: 41710768](https://pubmed.ncbi.nlm.nih.gov/41710768/). *Frontiers in child and adolescent psychiatry*. [Case Report / Case Series]
Kono T (2026). [PMID: 42221410](https://pubmed.ncbi.nlm.nih.gov/42221410/). *AACE Endocrinol Diabetes*. [Case Report / Case Series]
Pereira de Souza SC (2026). [PMID: 41921423](https://pubmed.ncbi.nlm.nih.gov/41921423/). *J Comp Pathol*. [Diagnostic / Biomarker]
Nakashima M (2026). [PMID: 41292152](https://pubmed.ncbi.nlm.nih.gov/41292152/). *Cancer Sci*. [Basic Science / Preclinical]
Miller HK (2026). [PMID: 42111021](https://pubmed.ncbi.nlm.nih.gov/42111021/). *Neurooncol Pract*. [Epidemiology / Natural History]
Huynh J (2026). [PMID: 41354280](https://pubmed.ncbi.nlm.nih.gov/41354280/). *Urology*. [Case Report / Case Series]