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A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes.
Biomarker and diagnostic research for seminoma has been reported in the published literature.
21 clinical trials registered, 9 recruiting. Interventions under study include procedural interventions, drug therapy, other interventions, and biologic therapy. Pipeline includes 3 PHASE3, 8 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06133543](https://clinicaltrials.gov/study/NCT06133543) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:35 PM UTC
Robot-assisted ICG-guided Sentinel Node Biopsy in Testicular Cancer |
NA |
Heinrich-Heine University, Duesseldorf |
RECRUITING |
[NCT04914026](https://clinicaltrials.gov/study/NCT04914026) | MicroRNA as Markers in Testicular Cancer | — | Haukeland University Hospital | RECRUITING |
[NCT05345158](https://clinicaltrials.gov/study/NCT05345158) | R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma | NA | University Health Network, Toronto | RECRUITING |
[NCT06309745](https://clinicaltrials.gov/study/NCT06309745) | THERApy De-escalation for TESTicular Cancer | — | Queen Mary University of London | RECRUITING |
[NCT07498959](https://clinicaltrials.gov/study/NCT07498959) | Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer | NA | Sahlgrenska University Hospital | RECRUITING |
221 publications have been identified in PubMed for seminoma. Research spans Case Report / Case Series (25%), Epidemiology / Natural History (21%), and Review / Meta-Analysis (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 56 | 25% |
Disease patterns and progression | 47 | 21% |
Research summaries | 32 | 14% |
Laboratory research | 32 | 14% |
Testing and diagnosis research | 24 | 11% |
Clinical study results | 21 | 10% |
Other research | 6 | 3% |
New treatment approaches | 3 | 1% |
Pereira M (2026). [PMID: 42071968](https://pubmed.ncbi.nlm.nih.gov/42071968/). *Animals (Basel)*. [Review / Meta-Analysis]
Choiniere R (2026). [PMID: 41717809](https://pubmed.ncbi.nlm.nih.gov/41717809/). *Histopathology*. [Diagnostic / Biomarker]
Di Costanzo F (2026). [PMID: 40494333](https://pubmed.ncbi.nlm.nih.gov/40494333/). *Oncology research and treatment*. [Clinical Trial Publication]
Wu Z (2026). [PMID: 41485106](https://pubmed.ncbi.nlm.nih.gov/41485106/). *J Natl Cancer Inst*. [Epidemiology / Natural History]
Cheaib JG (2026). [PMID: 42034485](https://pubmed.ncbi.nlm.nih.gov/42034485/). *Urol Oncol*. [Diagnostic / Biomarker]
Mousa A (2026). [PMID: 41934019](https://pubmed.ncbi.nlm.nih.gov/41934019/). *Urol Oncol*. [Basic Science / Preclinical]
Kapoor M (2026). [PMID: 32644342](https://pubmed.ncbi.nlm.nih.gov/32644342/). *Unknown Journal*. [Clinical Trial Publication]
Nappi L (2026). [PMID: 41997294](https://pubmed.ncbi.nlm.nih.gov/41997294/). *Ann Oncol*. [Other]
Chow KVC (2026). [PMID: 41607262](https://pubmed.ncbi.nlm.nih.gov/41607262/). *Asia Pac J Clin Oncol*. [Case Report / Case Series]
Kaimi Y (2026). [PMID: 41765467](https://pubmed.ncbi.nlm.nih.gov/41765467/). *J Clin Exp Hematop*. [Case Report / Case Series]