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HHV-6 encephalitis refers to inflammation of the brain due to an infection with human herpesvirus 6. People who have undergone allogeneic hematopoietic cell transplantation are at an increased risk for developing HHV-6 encephalitis, particularly when umbilical cord blood stem cells are used. People with immune system disorders may also be at an increased risk for developing this infection. Signs and symptoms vary, but often include confusion, anterograde amnesia (difficulty learning new information following the onset of amnesia), short-term memory loss, and seizures.Diagnosis often involves lumbar puncture, virus testing, and MRI. EEG 's may also be recommendedwhen seizures are suspected. HHV-6 encephalitis is treated with an antiviral agent with activity against HHV-6. Long term outlook (chance of full recovery) can vary considerably depending individual patient factors.
Biomarker and diagnostic research for HHV-6 encephalitis has been reported in the published literature.
No clinical trials have been registered for HHV-6 encephalitis.
196 publications have been identified in PubMed for HHV-6 encephalitis. Kisho has analyzed 131 by research type. Research spans Basic Science / Preclinical (29%), Review / Meta-Analysis (24%), and Case Report / Case Series (22%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 38 | 29% |
Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC
Genetic and Rare Diseases Info Center
Common questions about HHV-6 encephalitis
Research summaries
31 |
24% |
Patient case studies | 29 | 22% |
Disease patterns and progression | 15 | 11% |
Testing and diagnosis research | 9 | 7% |
Clinical study results | 7 | 5% |
Other research | 2 | 2% |
Yoshitake S (2026). [PMID: 41692477](https://pubmed.ncbi.nlm.nih.gov/41692477/). *Rinsho shinkeigaku = Clinical neurology*. [Review / Meta-Analysis]
Khalid A (2026). [PMID: 41769134](https://pubmed.ncbi.nlm.nih.gov/41769134/). *Sage open pediatrics*. [Case Report / Case Series]
Shiratori S (2026). [PMID: 41205871](https://pubmed.ncbi.nlm.nih.gov/41205871/). *Transplantation and cellular therapy*. [Clinical Trial Publication]
King O (2026). [PMID: 31082042](https://pubmed.ncbi.nlm.nih.gov/31082042/). *Unknown Journal*. [Review / Meta-Analysis]
Tang J (2026). [PMID: 41273932](https://pubmed.ncbi.nlm.nih.gov/41273932/). *Diagnostic microbiology and infectious disease*. [Diagnostic / Biomarker]
Lan J (2026). [PMID: 41043774](https://pubmed.ncbi.nlm.nih.gov/41043774/). *Transplantation and cellular therapy*. [Case Report / Case Series]
Yamasaki S (2026). [PMID: 41538306](https://pubmed.ncbi.nlm.nih.gov/41538306/). *Blood advances*. [Epidemiology / Natural History]
Ahn SH (2026). [PMID: 41530932](https://pubmed.ncbi.nlm.nih.gov/41530932/). *Encephalitis (Seoul, Korea)*. [Case Report / Case Series]
Yilmaz İ (2026). [PMID: 41709295](https://pubmed.ncbi.nlm.nih.gov/41709295/). *The Pediatric infectious disease journal*. [Case Report / Case Series]
Krishnan MS (2026). [PMID: 41889202](https://pubmed.ncbi.nlm.nih.gov/41889202/). *Pediatr Blood Cancer*. [Other]