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Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of immunoglobulin A and occasionally immunoglobulin G classes against epidermal basement membrane proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., vancomycin).
Features include very common findings: Autoimmunity, Abnormal blistering of the skin, and Papule; and common findings: Oral ulcer, Anti-LAD-1 antibody positivity, and Anti-LABD97 antibody positivity. 11 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 3 | Abnormal blistering of the skin, Papule, Pruritus |
Phenotype severity distribution: 3 very common features, 3 common features.
No clinical trials have been registered for linear IgA Dermatosis.
16 publications have been identified in PubMed for linear IgA Dermatosis. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (25%), and Other (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 8 | 50% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:53 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Lab test results
2 |
Anti-LAD-1 antibody positivity, Anti-LABD97 antibody positivity |
Blood and immune system | 1 | Autoimmunity |
Digestive system | 1 | Inflammation of the large intestine |
Kidneys and urinary system | 1 | Renal neoplasm |
4 |
25% |
Other research | 2 | 13% |
Clinical study results | 2 | 13% |
Yadav R (2026). [PMID: 41473884](https://pubmed.ncbi.nlm.nih.gov/41473884/). *Clin Case Rep*. [Case Report / Case Series]
Karaca Ural Z (2026). [PMID: 41578825](https://pubmed.ncbi.nlm.nih.gov/41578825/). *Eurasian J Med*. [Case Report / Case Series]
Nanpo H (2026). [PMID: 42183706](https://pubmed.ncbi.nlm.nih.gov/42183706/). *Eur J Dermatol*. [Clinical Trial Publication]
Wakisaka PS (2026). [PMID: 41875725](https://pubmed.ncbi.nlm.nih.gov/41875725/). *An Bras Dermatol*. [Clinical Trial Publication]
Lázaro Contreras AC (2026). [PMID: 41534399](https://pubmed.ncbi.nlm.nih.gov/41534399/). *Med Clin (Barc)*. [Other]
Castillo-Pinto S (2026). [PMID: 41285663](https://pubmed.ncbi.nlm.nih.gov/41285663/). *Arch Pediatr*. [Review / Meta-Analysis]
Nanda A (2026). [PMID: 41678328](https://pubmed.ncbi.nlm.nih.gov/41678328/). *J Eur Acad Dermatol Venereol*. [Review / Meta-Analysis]
Pandya A (2025). [PMID: 40073311](https://pubmed.ncbi.nlm.nih.gov/40073311/). *N Engl J Med*. [Case Report / Case Series]
Jiang R (2025). [PMID: 40129457](https://pubmed.ncbi.nlm.nih.gov/40129457/). *JAAD Case Rep*. [Case Report / Case Series]
Pointeaux L (2025). [PMID: 40905883](https://pubmed.ncbi.nlm.nih.gov/40905883/). *Clin Toxicol (Phila)*. [Case Report / Case Series]
AI-curated news mentioning linear IgA Dermatosis
Updated Aug 21, 2026
A recent study published in PubMed explores linear IgA/IgG bullous dermatosis, highlighting atypical mixed linear and granular immune complex deposition. This research contributes to the understanding of the disease's immunological mechanisms.
A case report details the management of recurrent linear IgA dermatosis in children without histopathology or immunofluorescence in a low-resource setting in Uganda. This study highlights the challenges and approaches in treating this rare skin condition.
A recent case study highlights the diagnostic challenges of linear IgA bullous dermatosis in children, particularly when ocular involvement is present. This research underscores the complexity of diagnosing rare skin conditions in pediatric patients.