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Mucous membrane pemphigoid is a bullous dermatosis characterized clinically by blistering of the mucous membranes followed by scarring, and immunologically by IgG, IgA and/or C3 deposits on the epidermal basement membrane.
Features include very common findings: Autoimmunity and Oral mucosal blisters; and common findings: Gingivitis and Atypical scarring of skin. 7 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 3 | Atypical scarring of skin, Abnormal blistering of the skin, Oral mucosal blisters |
Biomarker and diagnostic research for mucous membrane pemphigoid has been reported in the published literature.
Phenotype severity distribution: 2 very common features, 2 common features.
Estimated prevalence: Unknown (Unknown prevalence).
5 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE3, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05954416](https://clinicaltrials.gov/study/NCT05954416) |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 1:59 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Eyes
2 |
Blindness, Cloudy or opaque cornea (corneal opacity) |
Blood and immune system | 1 | Autoimmunity |
FARD (RaDiCo Cohort) (RaDiCo-FARD)
— |
Institut National de la Santé Et de la Recherche Médicale, France |
RECRUITING |
[NCT04198740](https://clinicaltrials.gov/study/NCT04198740) | Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface | — | Centre hospitalier de l'Université de Montréal (CHUM) | UNKNOWN |
[NCT06926478](https://clinicaltrials.gov/study/NCT06926478) | Subconjunctival Humira for Boston Keratoprosthesis | PHASE1 | Massachusetts Eye and Ear Infirmary | NOT_YET_RECRUITING |
[NCT06412718](https://clinicaltrials.gov/study/NCT06412718) | Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies | — | IRCCS Ospedale San Raffaele | UNKNOWN |
[NCT03295383](https://clinicaltrials.gov/study/NCT03295383) | Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid | PHASE3 | University Hospital, Rouen | ACTIVE_NOT_RECRUITING |
183 publications have been identified in PubMed for mucous membrane pemphigoid. Kisho has analyzed 83 by research type. Research spans Case Report / Case Series (33%), Review / Meta-Analysis (25%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 27 | 33% |
Research summaries | 21 | 25% |
Disease patterns and progression | 12 | 14% |
Testing and diagnosis research | 7 | 8% |
Clinical study results | 7 | 8% |
Laboratory research | 6 | 7% |
Other research | 2 | 2% |
New treatment approaches | 1 | 1% |
Chernyshov PV (2026). [PMID: 40690334](https://pubmed.ncbi.nlm.nih.gov/40690334/). *Int J Dermatol*. [Review / Meta-Analysis]
Lam PD (2026). [PMID: 41660300](https://pubmed.ncbi.nlm.nih.gov/41660300/). *Therapeutic advances in ophthalmology*. [Case Report / Case Series]
Ferrari G (2026). [PMID: 41827440](https://pubmed.ncbi.nlm.nih.gov/41827440/). *Journal of clinical medicine*. [Case Report / Case Series]
Dienes S (2026). [PMID: 41689384](https://pubmed.ncbi.nlm.nih.gov/41689384/). *International journal of dermatology*. [Basic Science / Preclinical]
Verma A (2026). [PMID: 41521800](https://pubmed.ncbi.nlm.nih.gov/41521800/). *Ocular immunology and inflammation*. [Basic Science / Preclinical]
Nanda A (2026). [PMID: 41678328](https://pubmed.ncbi.nlm.nih.gov/41678328/). *J Eur Acad Dermatol Venereol*. [Review / Meta-Analysis]
Luboń W (2026). [PMID: 41744821](https://pubmed.ncbi.nlm.nih.gov/41744821/). *Cells*. [Review / Meta-Analysis]
Shawver J (2025). [PMID: 39751769](https://pubmed.ncbi.nlm.nih.gov/39751769/). *Ophthalmology and therapy*. [Review / Meta-Analysis]
Truong-Balderas K (2025). [PMID: 40873394](https://pubmed.ncbi.nlm.nih.gov/40873394/). *Ocular immunology and inflammation*. [Case Report / Case Series]
Nguyen C (2025). [PMID: 40368030](https://pubmed.ncbi.nlm.nih.gov/40368030/). *The ocular surface*. [Case Report / Case Series]
AI-curated news mentioning mucous membrane pemphigoid
Updated Sep 16, 2026
A study highlights the diagnostic journey of mucous membrane pemphigoid, revealing significant referral delays at a tertiary dermatology center in Japan. Understanding these pathways can improve timely diagnosis and treatment for patients.
A new study highlights the association between mucous membrane pemphigoid and thymoma, shedding light on this rare cancer-related immune condition. This discovery may influence future research and treatment strategies for affected patients.
A recent study published in PubMed highlights the incidence and mortality rates of mucous membrane pemphigoid in France, providing valuable epidemiological data for researchers and healthcare professionals. This research contributes to the understanding of the disease's impact on patient populations.