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subcorneal pustular dermatosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

subcorneal pustular dermatosis

MONDO:0006614

Also known as:Sneddon-Wilkinson diseaseSneddon-Wilkinson disease or syndromepustulosis subcornealis

Overview

A rare, benign, chronic disease characterized by sterile pustular eruption, typically involving the flexural sites of the trunk and proximal extremities.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Hyperpigmentation of the skin, Erythema, and Pustule; and common findings: Pruritus. 11 total HPO annotations.

Organ System	Phenotype Count	Example Features
Skin	4	Hyperpigmentation of the skin, Pruritus, Systemic lupus erythematosus

Prognosis

Phenotype severity distribution: 3 very common features, 1 common feature.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for subcorneal pustular dermatosis.

120 publications have been identified in PubMed for subcorneal pustular dermatosis. Research spans Review / Meta-Analysis (65%), Case Report / Case Series (16%), and Epidemiology / Natural History (9%).

Research Type	Count	% of Total
Research summaries	68	65%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:48377

GARD

Genetic and Rare Diseases Info Center

GARD:13606

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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subcorneal pustular dermatosis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

subcorneal pustular dermatosis

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications