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ocular cicatricial pemphigoid - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

ocular cicatricial pemphigoid

MONDO:0008109

Also known as:ocular pemphigoidOCPcicatricial pemphigoid, ocular

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Overview

Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes. In the early stages, people with OCPgenerally experience chronic or relapsing conjunctivitis that is often characterized by tearing, irritation, burning, and/or mucus drainage. If left untreated, OCP can progress to severe conjunctiva scarring and vision loss. Involvement of other mucosal sites and the skin may also occur in OCP. The exact underlying cause is currently unknown. The treatment of OCP aims to slow disease progression and prevent complications. This usually involves long-term use of medications called immunomodulators which help regulate or normalize the immune system.

GeneticsAutosomal dominant

Clinical Trials2 registered

Clinical Presentation

Features include: Abnormality of the eye.

Organ System	Phenotype Count	Example Features
Eyes	1	Abnormality of the eye

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Diagnosis

Biomarker and diagnostic research for ocular cicatricial pemphigoid has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered. Interventions under study include drug therapy. Pipeline includes 1 PHASE1. Research is primarily sponsored by academic and government institutions.

58 publications have been identified in PubMed for ocular cicatricial pemphigoid. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (17%), and Clinical Trial Publication (16%).

Research Type	Count	% of Total
Patient case studies	18	31%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 3:32 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:164185

Orphanet

European rare disease database

Orphanet:99922

GARD

Genetic and Rare Diseases Info Center

GARD:8759

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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ocular cicatricial pemphigoid

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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