Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

pili gemini - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pili gemini

MONDO:0019330

Also known as:pili multigemini

Overview

Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair.

ResearchLimited published research (7 articles)

Clinical Presentation

Features include always present findings: Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes; and common findings: Abnormal hairshaft morphology.

Explore clinical features

Prognosis

Phenotype severity distribution: 1 always present feature, 1 common feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for pili gemini.

7 publications have been identified in PubMed for pili gemini. Research spans Basic Science / Preclinical (57%) and Case Report / Case Series (43%).

Recent Publications

Zhong X (2026). [PMID: 41626003](https://pubmed.ncbi.nlm.nih.gov/41626003/). *JAAD Case Rep*. [Case Report / Case Series]
Saleh HM (2026). [PMID: 28613486](https://pubmed.ncbi.nlm.nih.gov/28613486/). *Unknown Journal*. [Case Report / Case Series]
Hilzinger JM (2025). [PMID: 39392130](https://pubmed.ncbi.nlm.nih.gov/39392130/). *Biotechnol Bioeng*. [Basic Science / Preclinical]
Rosko J (2025). [PMID: 40693898](https://pubmed.ncbi.nlm.nih.gov/40693898/). *Elife*. [Basic Science / Preclinical]
Davidson E (2025). [PMID: 39168482](https://pubmed.ncbi.nlm.nih.gov/39168482/). *Pediatr Dermatol*. [Case Report / Case Series]
Yu H (2025). [PMID: 40845095](https://pubmed.ncbi.nlm.nih.gov/40845095/). *Sci Adv*. [Basic Science / Preclinical]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:79492

GARD

Genetic and Rare Diseases Info Center

GARD:19026

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

pili gemini

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team