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uncombable hair syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

uncombable hair syndrome

MONDO:0008621

Also known as:pili trianguli et canaliculicheveux incoiffablesspun glass hair

Overview

Uncombable hair syndrome (UHS), or pili trianguli et canaliculi, is a rare scalp hair shaft dysplasia.

ResearchLimited published research (8 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abnormal hair morphology, Coarse hair, Woolly hair, and Trichodysplasia and others; and sometimes findings: Patchy alopecia.

Organ System	Phenotype Count	Example Features
Skin	1	Patchy alopecia

Explore clinical features

Diagnosis

Biomarker and diagnostic research for uncombable hair syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 5 very common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for uncombable hair syndrome.

8 publications have been identified in PubMed for uncombable hair syndrome. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (25%), and Diagnostic / Biomarker (13%).

Recent Publications

Fogla N (2025). [PMID: 40177805](https://pubmed.ncbi.nlm.nih.gov/40177805/). *Pediatr Dermatol*. [Diagnostic / Biomarker]
Sechi A (2025). [PMID: 39731451](https://pubmed.ncbi.nlm.nih.gov/39731451/). *Pediatr Dermatol*. [Case Report / Case Series]
Yu F (2025). [PMID: 41002404](https://pubmed.ncbi.nlm.nih.gov/41002404/). *Cells*. [Review / Meta-Analysis]
Li Y (2024). [PMID: 39092871](https://pubmed.ncbi.nlm.nih.gov/39092871/). *J Dtsch Dermatol Ges*. [Case Report / Case Series]
Roberson JL (2024). [PMID: 38902823](https://pubmed.ncbi.nlm.nih.gov/38902823/). *Dis Colon Rectum*. [Basic Science / Preclinical]
Heyers A (2024). [PMID: 38641557](https://pubmed.ncbi.nlm.nih.gov/38641557/). *Clin Exp Dermatol*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:12 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1410

GARD

Genetic and Rare Diseases Info Center

GARD:5404

Questions for Your Care Team

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uncombable hair syndrome

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team