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ringed hair disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

ringed hair disease

MONDO:0008388

Also known as:pili annulatiringed hair

Overview

Pili annulati is an isolated, benign hair shaft abnormality, usually presenting after the age of 2 and affecting the hair of the scalp or very rarely beard, axillary, or pubic hair, that is characterized by a banded or speckled appearance due to alternating light bands (corresponding to air-filled cavities within the cortex of the affected hair shafts) and dark bands. The bands have a lifelong duration, may only be detectable under light microscopy, are more apparent in fair-colored hair or with age-related graying, and have no effect on hair growth or fragility in the vast majority of cases.

GeneticsAutosomal dominant

ResearchLimited published research (9 articles)

Clinical Presentation

Features include very common findings: Fine hair and Abnormal hair pattern. 3 total HPO annotations.

Explore clinical features

Diagnosis

Biomarker and diagnostic research for ringed hair disease has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 very common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for ringed hair disease.

9 publications have been identified in PubMed for ringed hair disease. Research spans Diagnostic / Biomarker (22%), Review / Meta-Analysis (22%), and Case Report / Case Series (22%).

Recent Publications

Chabchoub I (2026). [PMID: 31082025](https://pubmed.ncbi.nlm.nih.gov/31082025/). *Unknown Journal*. [Other]
Maram L (2025). [PMID: 39708766](https://pubmed.ncbi.nlm.nih.gov/39708766/). *European journal of medicinal chemistry*. [Gene Therapy / Novel Therapeutics]
Chen S (2025). [PMID: 39223435](https://pubmed.ncbi.nlm.nih.gov/39223435/). *Clinical and experimental dermatology*. [Review / Meta-Analysis]
Öztürk Durmaz E (2025). [PMID: 39602112](https://pubmed.ncbi.nlm.nih.gov/39602112/). *JAMA dermatology*. [Case Report / Case Series]
Islam NU (2025). [PMID: 40743748](https://pubmed.ncbi.nlm.nih.gov/40743748/). *Journal of basic and clinical physiology and pharmacology*. [Review / Meta-Analysis]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:180600

Orphanet

European rare disease database

Orphanet:169

GARD

Genetic and Rare Diseases Info Center

GARD:4359

Questions for Your Care Team

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ringed hair disease

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team