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ricin poisoning - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

ricin poisoning

MONDO:0035511

Overview

A rare disorder due to poisoning characterized by acute onset of potentially life-threatening illness following ingestion, inhalation, or injection of ricin, a lectin present in the seeds of <i>Ricinus communis</i>, the castor oil plant. Clinical presentation depends on the route of administration, inhalation being the most toxic route, followed by oral ingestion. Presenting signs and symptoms include nausea, vomiting, diarrhea, hematemesis, and melena (upon ingestion), cough, wheezing, dyspnea, sore throat, and congestion (upon inhalation), and erythema, induration, blisters, capillary leak syndrome, and localized necrosis (upon injection). The condition can progress to seizures, shock, organ failure, pulmonary edema, and respiratory failure.

TreatmentsNo approved treatments · 1 in pipeline

ResearchLimited published research (8 articles)

Diagnosis

Biomarker and diagnostic research for ricin poisoning has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for ricin poisoning. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for ricin poisoning, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for ricin poisoning. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for ricin poisoning.

8 publications have been identified in PubMed for ricin poisoning. Research spans Case Report / Case Series (25%), Basic Science / Preclinical (25%), and Gene Therapy / Novel Therapeutics (25%).

Recent Publications

Botelho FD (2026). [PMID: 41768622](https://pubmed.ncbi.nlm.nih.gov/41768622/). *ACS Omega*. [Basic Science / Preclinical]
Marin RE (2026). [PMID: 41560680](https://pubmed.ncbi.nlm.nih.gov/41560680/). *J Vet Diagn Invest*. [Epidemiology / Natural History]
Rauniyar Z (2025). [PMID: 41180702](https://pubmed.ncbi.nlm.nih.gov/41180702/). *Ann Med Surg (Lond)*. [Case Report / Case Series]
Biscotti F (2025). [PMID: 40864076](https://pubmed.ncbi.nlm.nih.gov/40864076/). *Toxins (Basel)*. [Basic Science / Preclinical]
Dixit S (2024). [PMID: 38574703](https://pubmed.ncbi.nlm.nih.gov/38574703/). *Int Immunopharmacol*. [Diagnostic / Biomarker]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:12 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:570470

GARD

Genetic and Rare Diseases Info Center

GARD:22311

Questions for Your Care Team

→What is the current development status of Ricin Immune Fab, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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ricin poisoning

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials