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Biomarker and diagnostic research for spontaneous intracranial hypotension has been reported in the published literature.
7 clinical trials registered, 3 recruiting. Interventions under study include other interventions and procedural interventions. Pipeline includes 3 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05922514](https://clinicaltrials.gov/study/NCT05922514) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 2:54 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
A Clinical Registry of Spontaneous Intracranial Hypotension
— |
Mayo Clinic |
RECRUITING |
[NCT07085260](https://clinicaltrials.gov/study/NCT07085260) | ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension | — | Yonsei University | UNKNOWN |
[NCT06805591](https://clinicaltrials.gov/study/NCT06805591) | Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study | — | Danish Headache Center | ENROLLING_BY_INVITATION |
[NCT07283536](https://clinicaltrials.gov/study/NCT07283536) | Blind Versus Targeted Epidural Patch With Autologous Platelet-rich Plasma for Spontaneous Intracranial Hypotension | NA | Beijing Tiantan Hospital | UNKNOWN |
[NCT06374524](https://clinicaltrials.gov/study/NCT06374524) | Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension | — | University Health Network, Toronto | RECRUITING |
234 publications have been identified in PubMed for spontaneous intracranial hypotension. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (23%), and Diagnostic / Biomarker (16%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 73 | 31% |
Research summaries | 53 | 23% |
Testing and diagnosis research | 38 | 16% |
Disease patterns and progression | 31 | 13% |
Clinical study results | 15 | 6% |
Laboratory research | 15 | 6% |
Other research | 8 | 3% |
New treatment approaches | 1 | 0% |
Ryu B (2026). [PMID: 41999588](https://pubmed.ncbi.nlm.nih.gov/41999588/). *Neuroradiol J*. [Case Report / Case Series]
Miyake S (2026). [PMID: 41526251](https://pubmed.ncbi.nlm.nih.gov/41526251/). *Neurol Med Chir (Tokyo)*. [Case Report / Case Series]
Puello M (2026). [PMID: 41062183](https://pubmed.ncbi.nlm.nih.gov/41062183/). *AJNR Am J Neuroradiol*. [Epidemiology / Natural History]
He Y (2026). [PMID: 41617397](https://pubmed.ncbi.nlm.nih.gov/41617397/). *AJNR Am J Neuroradiol*. [Case Report / Case Series]
Hashimoto K (2026). [PMID: 42232430](https://pubmed.ncbi.nlm.nih.gov/42232430/). *Surg Neurol Int*. [Case Report / Case Series]
Wang Z (2026). [PMID: 42028923](https://pubmed.ncbi.nlm.nih.gov/42028923/). *Ann Neurol*. [Basic Science / Preclinical]
Parikh SK (2026). [PMID: 41090555](https://pubmed.ncbi.nlm.nih.gov/41090555/). *Headache*. [Review / Meta-Analysis]
Ciceri EFM (2026). [PMID: 41162638](https://pubmed.ncbi.nlm.nih.gov/41162638/). *Radiol Med*. [Review / Meta-Analysis]
Sharma S (2026). [PMID: 41633638](https://pubmed.ncbi.nlm.nih.gov/41633638/). *Neurol India*. [Case Report / Case Series]
Ryu B (2026). [PMID: 42055957](https://pubmed.ncbi.nlm.nih.gov/42055957/). *AJNR Am J Neuroradiol*. [Basic Science / Preclinical]
AI-curated news mentioning spontaneous intracranial hypotension
Updated Mar 13, 2026
A case series published in PubMed highlights symptomatic spontaneous intracranial hypotension due to cerebrospinal fluid leaks at the C1-C2 level, successfully sealed with an epidural blood patch. This review contributes to the understanding of treatment options for this rare condition.