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SUNCT syndrome (Short-lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing) is a primary headache disorder characterized by unilateral trigeminal pain that occurs in association with ipsilateral cranial autonomic symptoms (conjunctival injection and tearing).
Features include very common findings: Epiphora, Conjunctival hyperemia, and Episodic pain; and common findings: Ptosis, Restlessness, Agitation, and Excessive sweating (hyperhidrosis) and others. 23 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 3 | Agitation, Migraine, Trigeminal neuralgia |
Phenotype severity distribution: 3 very common features, 10 common features.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
No clinical trials have been registered for SUNCT syndrome.
24 publications have been identified in PubMed for SUNCT syndrome. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (21%), and Other (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 12 | 50% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:42 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about SUNCT syndrome
Skin
3 |
Excessive sweating (hyperhidrosis), Episodic hyperhidrosis, Facial erythema |
Eyes | 2 | Conjunctival hyperemia, Ptosis |
Head and neck | 2 | Facial edema, Facial erythema |
Digestive system | 2 | Nausea, Vomiting |
5 |
21% |
Other research | 3 | 13% |
Clinical study results | 2 | 8% |
Laboratory research | 1 | 4% |
Disease patterns and progression | 1 | 4% |
Al Khalili Y (2026). [PMID: 32644514](https://pubmed.ncbi.nlm.nih.gov/32644514/). *Unknown Journal*. [Other]
Bodle J (2026). [PMID: 32644406](https://pubmed.ncbi.nlm.nih.gov/32644406/). *Unknown Journal*. [Other]
Hameed S (2026). [PMID: 32491500](https://pubmed.ncbi.nlm.nih.gov/32491500/). *Unknown Journal*. [Other]
Sherratt-Mayhew S (2026). [PMID: 41690678](https://pubmed.ncbi.nlm.nih.gov/41690678/). *Canadian journal of ophthalmology. Journal canadien d'ophtalmologie*. [Case Report / Case Series]
Jansen JJ (2025). [PMID: 40303899](https://pubmed.ncbi.nlm.nih.gov/40303899/). *Pain reports*. [Case Report / Case Series]
Fernandes CS (2025). [PMID: 40888687](https://pubmed.ncbi.nlm.nih.gov/40888687/). *Cephalalgia : an international journal of headache*. [Clinical Trial Publication]
Ahmed Z (2025). [PMID: 41181417](https://pubmed.ncbi.nlm.nih.gov/41181417/). *Annals of medicine and surgery (2012)*. [Basic Science / Preclinical]
McClendon D (2025). [PMID: 41167853](https://pubmed.ncbi.nlm.nih.gov/41167853/). *Physical medicine and rehabilitation clinics of North America*. [Case Report / Case Series]
Demirel-Ozbek E (2025). [PMID: 40979274](https://pubmed.ncbi.nlm.nih.gov/40979274/). *Neuro-ophthalmology (Aeolus Press)*. [Case Report / Case Series]
Sampaio Rocha-Filho PA (2025). [PMID: 40711126](https://pubmed.ncbi.nlm.nih.gov/40711126/). *Toxins*. [Review / Meta-Analysis]