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cluster headache syndrome - Clinical Profile, Treatments & Trials | Kisho | Kisho

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

2 FDA-approved treatments are available for cluster headache syndrome, including SUMATRIPTAN (IMITREX, approved 1992) and GALCANEZUMAB-GNLM (EMGALITY, approved 2018).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status
EMGALITY	GALCANEZUMAB-GNLM	—	2018	Available
IMITREX	SUMATRIPTAN	—	1992	Available

Gene therapy approaches for cluster headache syndrome have been reported in the published literature.

Clinical Trials

29 trials found

Explore Trials

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

29 clinical trials registered, 16 recruiting. Interventions under study include drug therapy, other interventions, medical devices, and procedural interventions. Pipeline includes 2 PHASE4, 2 PHASE3, 5 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05324748](https://clinicaltrials.gov/study/NCT05324748)	Repeated GON Injections in CCH	PHASE3	Leiden University Medical Center	RECRUITING
[NCT04930887](https://clinicaltrials.gov/study/NCT04930887)	Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain	PHASE2	Stanford University	RECRUITING
[NCT06540651](https://clinicaltrials.gov/study/NCT06540651)	Efficacy of Light Therapy in Treatment of Chronic Cluster Headache	NA	Assistance Publique Hopitaux De Marseille	RECRUITING
[NCT05477459](https://clinicaltrials.gov/study/NCT05477459)	LSD to Improve Cluster Headache Impact Trial	PHASE2	Radboud University Medical Center	RECRUITING
[NCT03781128](https://clinicaltrials.gov/study/NCT03781128)	Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache	PHASE2	University Hospital, Basel, Switzerland	RECRUITING

106 publications have been identified in PubMed for cluster headache syndrome. Research spans Review / Meta-Analysis (48%), Epidemiology / Natural History (18%), and Basic Science / Preclinical (12%).

Research Type	Count	% of Total
Research summaries	51	48%
Disease patterns and progression	19	18%
Laboratory research	13	12%
Clinical study results	11	10%
Patient case studies	5	5%
New treatment approaches	3

Recent Publications

Bodle J (2026). [PMID: 32644406](https://pubmed.ncbi.nlm.nih.gov/32644406/). *Unknown Journal*. [Basic Science / Preclinical]
Lundy JA (2026). [PMID: 31424892](https://pubmed.ncbi.nlm.nih.gov/31424892/). *Unknown Journal*. [Basic Science / Preclinical]
Patel P (2026). [PMID: 31424856](https://pubmed.ncbi.nlm.nih.gov/31424856/). *Unknown Journal*. [Basic Science / Preclinical]
Lian F (2026). [PMID: 41879092](https://pubmed.ncbi.nlm.nih.gov/41879092/). *J Pathol*. [Basic Science / Preclinical]
Brandt RB (2026). [PMID: 41575239](https://pubmed.ncbi.nlm.nih.gov/41575239/). *Cephalalgia*. [Other]
GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators (2026). [PMID: 42229499](https://pubmed.ncbi.nlm.nih.gov/42229499/). *Lancet Infect Dis*. [Epidemiology / Natural History]
Shah RJ (2026). [PMID: 30725629](https://pubmed.ncbi.nlm.nih.gov/30725629/). *Unknown Journal*. [Gene Therapy / Novel Therapeutics]
Zhang L (2026). [PMID: 42136349](https://pubmed.ncbi.nlm.nih.gov/42136349/). *Zhongguo Yi Xue Ke Xue Yuan Xue Bao*. [Case Report / Case Series]
Serrão C (2026). [PMID: 41044859](https://pubmed.ncbi.nlm.nih.gov/41044859/). *Headache*. [Case Report / Case Series]
Kollenburg L (2026). [PMID: 40995873](https://pubmed.ncbi.nlm.nih.gov/40995873/). *Brain*. [Review / Meta-Analysis]

Kisho

cluster headache syndrome

Overview

Diagnosis

Treatment

Approved Therapies

Clinical Trials

Research Landscape

Recent Publications

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Latest News & Developments

Screening for Mild Vertebral Artery Dissection Using 3-Dimensional T1-weighted Black-blood Magnetic Resonance Imaging: A Retrospective Observational Study of 3,049 Consecutive Walk-in Patients Presenting with Headache.

cluster headache syndrome

Overview

Diagnosis

Treatment

Approved Therapies

Clinical Trials

Research Landscape

Recent Publications

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Latest News & Developments

Screening for Mild Vertebral Artery Dissection Using 3-Dimensional T1-weighted Black-blood Magnetic Resonance Imaging: A Retrospective Observational Study of 3,049 Consecutive Walk-in Patients Presenting with Headache.