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A superficial fibromatosis arising from soft tissue of the plantar regions. It is characterized by the presence of spindle-shaped fibroblasts, hypercellularity, and an infiltrative growth pattern.
Features include very common findings: Arthralgia, Paresthesia, and Lack of skin elasticity; and common findings: Subcutaneous nodule. 5 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 2 | Subcutaneous nodule, Lack of skin elasticity |
Biomarker and diagnostic research for plantar fibromatosis has been reported in the published literature.
Phenotype severity distribution: 3 very common features, 1 common feature.
1 clinical trial registered. Interventions under study include other interventions and biologic therapy. Pipeline includes 1 PHASE3. Research is primarily industry-sponsored.
18 publications have been identified in PubMed for plantar fibromatosis. Research spans Review / Meta-Analysis (29%), Case Report / Case Series (24%), and Epidemiology / Natural History (24%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 5 | 29% |
Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 8:47 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
2 |
Paresthesia, Peripheral neuropathy |
Bones and joints | 1 | Arthralgia |
Patient case studies |
4 |
24% |
Disease patterns and progression | 4 | 24% |
Testing and diagnosis research | 2 | 12% |
Clinical study results | 2 | 12% |
Skalli S (2026). [PMID: 41732541](https://pubmed.ncbi.nlm.nih.gov/41732541/). *Radiology case reports*. [Case Report / Case Series]
Rühle A (2026). [PMID: 41391891](https://pubmed.ncbi.nlm.nih.gov/41391891/). *Seminars in radiation oncology*. [Review / Meta-Analysis]
Davis J (2026). [PMID: 41519372](https://pubmed.ncbi.nlm.nih.gov/41519372/). *The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons*. [Epidemiology / Natural History]
Velez N (2026). [PMID: 40958075](https://pubmed.ncbi.nlm.nih.gov/40958075/). *Skeletal radiology*. [Epidemiology / Natural History]
Carroll P (2026). [PMID: 41744518](https://pubmed.ncbi.nlm.nih.gov/41744518/). *Clinics and practice*. [Case Report / Case Series]
Sideris GA (2026). [PMID: 42024245](https://pubmed.ncbi.nlm.nih.gov/42024245/). *Pediatr Radiol*. [Review / Meta-Analysis]
Tedeschi R (2026). [PMID: 42238076](https://pubmed.ncbi.nlm.nih.gov/42238076/). *Clin Med Insights Arthritis Musculoskelet Disord*. [Clinical Trial Publication]
Ramar SY (2025). [PMID: 40826861](https://pubmed.ncbi.nlm.nih.gov/40826861/). *Indian journal of dermatology, venereology and leprology*. [Case Report / Case Series]
Analay P (2025). [PMID: 40152055](https://pubmed.ncbi.nlm.nih.gov/40152055/). *Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine*. [Review / Meta-Analysis]
Althobaiti AS (2025). [PMID: 41018462](https://pubmed.ncbi.nlm.nih.gov/41018462/). *Cureus*. [Epidemiology / Natural History]
AI-curated news mentioning plantar fibromatosis
Updated Feb 13, 2026
A recent case report highlights the use of ultrasound in diagnosing and managing plantar fibromatosis, also known as Ledderhose disease. This study contributes to the understanding of non-invasive diagnostic techniques for this rare condition.