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A very rare form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and is due to intestinal colonization by Clostridium botulinum leading to toxin-mediated infection with toxemia.
Features include very common findings: Ptosis, Diplopia, Muscle weakness, and Diaphragmatic paralysis and others; and common findings: Diarrhea, Dyspnea, and Difficulty breathing due to muscle weakness (respiratory insufficiency due to muscle weakness).
Organ System | Phenotype Count | Example Features |
|---|---|---|
Eyes | 2 | Ptosis, Diplopia |
Phenotype severity distribution: 6 very common features, 3 common features.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for adult intestinal botulism.
7 publications have been identified in PubMed for adult intestinal botulism. Research spans Case Report / Case Series (67%), Review / Meta-Analysis (17%), and Epidemiology / Natural History (17%).
Kihara K (2026). [PMID: 42156031](https://pubmed.ncbi.nlm.nih.gov/42156031/). *Brain Nerve*. [Review / Meta-Analysis]
Pourshams I (2025). [PMID: 40385703](https://pubmed.ncbi.nlm.nih.gov/40385703/). *Gastro Hep Adv*. [Case Report / Case Series]
Jiang R (2025). [PMID: 40847385](https://pubmed.ncbi.nlm.nih.gov/40847385/). *BMC Neurol*. [Case Report / Case Series]
Adams L (2025). [PMID: 39981031](https://pubmed.ncbi.nlm.nih.gov/39981031/). *Case Rep Neurol*. [Case Report / Case Series]
Cohen R (2025). [PMID: 41591082](https://pubmed.ncbi.nlm.nih.gov/41591082/). *Neurol Int*. [Case Report / Case Series]
Harris RA (2024). [PMID: 39179697](https://pubmed.ncbi.nlm.nih.gov/39179697/). *Curr Microbiol*. [Epidemiology / Natural History]
Data assembled from 4 of 12 sources · Last updated Oct 3, 2026, 8:12 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about adult intestinal botulism
Muscles
2 |
Muscle weakness, Difficulty breathing due to muscle weakness (respiratory insufficiency due to muscle weakness) |
Lungs and breathing | 2 | Dyspnea, Difficulty breathing due to muscle weakness (respiratory insufficiency due to muscle weakness) |
Brain and nerves | 2 | Cranial nerve paralysis, Cerebral palsy |
Digestive system | 1 | Diarrhea |