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infant botulism - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

infant botulism

MONDO:0015804

Also known as:botulism of infancyinfant intestinal botulisminfant intestinal toxaemia botulism

Overview

A botulism that occurs between 28 days to one year of life..

Treatments1 FDA approved

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Xerostomia, Mask-like facies, Ptosis, and Diplopia and others; and common findings: Abnormality of the pharynx, Hypertension, Areflexia, and Dyspnea and others. 28 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	5	Dysarthria, Difficulty swallowing (dysphagia), Cranial nerve paralysis

Diagnosis

Biomarker and diagnostic research for infant botulism has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for infant botulism, including Botulism Immune Globulin Intravenous (Human) (BabyBig, approved 2003).

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Phenotype severity distribution: 17 very common features, 7 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for infant botulism.

42 publications have been identified in PubMed for infant botulism. Research spans Case Report / Case Series (33%), Epidemiology / Natural History (29%), and Review / Meta-Analysis (21%).

Research Type	Count	% of Total
Patient case studies	14	33%

Data assembled from 5 of 12 sources · Last updated Oct 3, 2026, 8:09 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:178478

GARD

Genetic and Rare Diseases Info Center

GARD:20150

Questions for Your Care Team

→What are the benefits and potential side effects of BabyBig for managing infant botulism?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

infant botulism

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

Botulism Type F, a Rare Type of Botulism that Can Masquerade as a Posterior Fossa Stroke.

Botulism Prevention

People at Increased Risk for Botulism

About Botulism

Timeliness and diagnostic yield of suspected botulism notifications in a tertiary medical center in Taiwan, 2014-2024.

infant botulism

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

Botulism Type F, a Rare Type of Botulism that Can Masquerade as a Posterior Fossa Stroke.

Botulism Prevention

People at Increased Risk for Botulism

About Botulism

Timeliness and diagnostic yield of suspected botulism notifications in a tertiary medical center in Taiwan, 2014-2024.